ID G3T2F5_LOXAF Unreviewed; 632 AA.
AC G3T2F5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Plastin 1 {ECO:0000313|Ensembl:ENSLAFP00000007347.3};
GN Name=PLS1 {ECO:0000313|Ensembl:ENSLAFP00000007347.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007347.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000007347.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007347.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000007347.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007347.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3T2F5; -.
DR STRING; 9785.ENSLAFP00000007347; -.
DR Ensembl; ENSLAFT00000008746.3; ENSLAFP00000007347.3; ENSLAFG00000008746.3.
DR eggNOG; KOG0046; Eukaryota.
DR GeneTree; ENSGT00950000183097; -.
DR HOGENOM; CLU_015284_2_0_1; -.
DR InParanoid; G3T2F5; -.
DR OMA; DDIIIKW; -.
DR TreeFam; TF300680; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR GO; GO:1990357; C:terminal web; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Ensembl.
DR GO; GO:0001951; P:intestinal D-glucose absorption; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0032532; P:regulation of microvillus length; IEA:Ensembl.
DR GO; GO:1902896; P:terminal web assembly; IEA:Ensembl.
DR GO; GO:0060121; P:vestibular receptor cell stereocilium organization; IEA:Ensembl.
DR CDD; cd21323; CH_PLS1_rpt1; 1.
DR CDD; cd21332; CH_PLS1_rpt4; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR PANTHER; PTHR19961:SF27; PLASTIN-1; 1.
DR Pfam; PF00307; CH; 4.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00033; CH; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 4.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..51
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 56..91
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 127..243
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 271..382
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 401..508
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 520..629
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 632 AA; 70963 MW; F3A48086BE7FC91B CRC64;
LSCPEMENST TTISREELEE LQEAFNKIDI DNSGYVSDYE LQDLFKEASL PLPGYKVREI
VEKIIAVADS SKDGRISFEE FVSLMQELKS KDISKTFRKI INKREGITAI GGTSSISSEG
TQHSYSEEEK VAFVNWINKA LENDPDCKHL IPMDPNDNSL FKSLADGILL CKMINLSEPD
TIDERAINKK KLTPFTISEN LNLALNSASA IGCTVVNIGA QDLKEGKPHL VLGLLWQIIK
VGLFADIEIS RNEALIALLN EGEELEELMK LSPEELLLRW VNYHLTNAGW RTISNFSQDI
KDSRAYFHLL NQIAPKGSRD DEPSIDIDMS GFNERNDLKR AEFMLQQADK LGCRQFVTPA
DVVSGNPKLN LAFVANLFNT YPSLRKPDNN DIDINLLEGE SKEERTFRNW MNSLGVNPYI
NHLYSDLADA LVIFQLYEMT RVPVDWGHVN KPPYPALGGN MKKIENCNYA VELGKDAKFS
LVGIAGQDNE GNATLTLALV WQLMRRYTLN VLSDLGEGEK VNDEIIIKWV NQTLKNANKK
TSISSFKDKS ISTSLPVLDL IDAIEPNAVR QEMIKREDLS DEDKLNNAKY AISVARKIGA
RIYALPDDLV EVKPKMVMTV FACLMGKGLN RV
//