ID G3T2J5_LOXAF Unreviewed; 997 AA.
AC G3T2J5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=LIM and calponin homology domains 1 {ECO:0000313|Ensembl:ENSLAFP00000007394.4};
GN Name=LIMCH1 {ECO:0000313|Ensembl:ENSLAFP00000007394.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007394.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000007394.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007394.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000007394.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007394.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3T2J5; -.
DR STRING; 9785.ENSLAFP00000007394; -.
DR Ensembl; ENSLAFT00000008801.4; ENSLAFP00000007394.4; ENSLAFG00000008797.4.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00950000183159; -.
DR HOGENOM; CLU_003242_1_0_1; -.
DR InParanoid; G3T2J5; -.
DR OMA; ENCHEEE; -.
DR TreeFam; TF332155; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR031865; DUF4757.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR15551:SF3; LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR15551; LIM DOMAIN ONLY 7; 1.
DR Pfam; PF15949; DUF4757; 1.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 932..997
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 106..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 275..360
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 106..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 112343 MW; 6E476182F82B072F CRC64;
DNIILFLRGC KELGLKESQL FDPSDLQDTS NRVAVKSLDY SRKLRNVLVT IYWLGKAANS
CASYSGATLN LKEFEGLLAQ MRKETDDIES PKRSIRDSGY IDCWDSERSD SLSPPRHGRD
DSFDSLDSFG SRSHQTPSPD VVLRGSSDGR GSDSESDLPH RKLPDVKKDD MSARRTSHGE
LKSAVPFNQY LPNKSNQTAY VPAPLRKKKA EREEYRKSWS TATSPLGGDR PFRYGPRTPV
SDDAESTSMF DVRCEEEAAV QPHSRARQEQ LQLINNQLRE EDDKWQDDLA RWKSRRRSVS
QDLIRKEEER KKMEKLLAGE DGTSERRKSI KTYREIVQEK ERRERELHEA YKNARSQEEA
EGILQQYIER FTISEAVLER LEMPKILERS HSAEPNLCPF LSDPNPMKYL RQQSLPPPKF
TAIVETTIAG TSVLDTSMLA GSGSPSKTVT PKAVPMLTPK PYSQPKNSQE VLKTFKVDGK
VSMNGEMIHG DEEKERECPT VALSPSLTKS QMFEGVATVH GSPVELKQGN NGIEINIKKP
NSVPQELTAT TEEAEPNSQE DENDGGKAEK GNTEFASSEP QHFTTTVTRS SPTVAFAEFS
SSPQLKTHVP EEKDQKKLEN EMSGKVELVL SQKVIKPKSP EPEATLTFPF LDKMPETNQL
HLPNLNSQVD SPSSEKSPVT TPFKFWAWNP EEERRRQEKW QQEQERLLQE RYQKEQDKLK
EEWEKAQKEV EEEERRYYEE ERKIIEDTVV PFTVSSSSAD QLSTSSSITE GSGTVNKMDL
ESCQEEGQER RQKKPLQEGD NDLLLKNSES DPLEEKRSLT QGALAHSENP VPKGIHQDQQ
LEAEAGAPHC GMSPQLSQDP SRNQQVLNPP TPISEDVKPK TLPLDKNINH QIESPSERRK
TSPQENFQAG HLSPCSPTPP GQSPNRSISG KKLCSSCGLP LGKGAAMIIE TLNLYFHIQC
FRCGICKGQL GDAVSGTDVR IRNGLLNCND CYMRSRS
//
