ID   G3T2K6_LOXAF            Unreviewed;       520 AA.
AC   G3T2K6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007407.2, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000007407.2, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007407.2,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000007407.2}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007407.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; G3T2K6; -.
DR   STRING; 9785.ENSLAFP00000007407; -.
DR   Ensembl; ENSLAFT00000008819.2; ENSLAFP00000007407.2; ENSLAFG00000008822.2.
DR   eggNOG; KOG1089; Eukaryota.
DR   GeneTree; ENSGT00940000163547; -.
DR   HOGENOM; CLU_001839_3_1_1; -.
DR   InParanoid; G3T2K6; -.
DR   OMA; CASYPPA; -.
DR   TreeFam; TF315197; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   CDD; cd14536; PTP-MTMR9; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807:SF52; MYOTUBULARIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          121..499
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
SQ   SEQUENCE   520 AA;  58502 MW;  391E59DFAD2BE15E CRC64;
     PQYSELMRTG RAQAELLLGP EAPRLRGTLC VTGHHLLLSP GPQDLWLLLL RNVDSIEKRV
     AGESGTITLR CKDLRVLQLD IEGVEATLDI ARSIEALSSL ESVITSFPFF YRPKGLRLGD
     AWHFHPPESY YKRVARETKA WRLSEVNENF SLCPSYPRAV IVPRAVDDKA LALSARFRQG
     GRFPVLSYHH ARSGTVLLRS SQPLTGPQKR RCAEDEELLR AVLAGARPGA QGFVVDTRSA
     QAAKQARMAG GGTEAKAAYP GWKRLHRPLE RGRPLQESFV RLVEACGDLE QSTDHWLSRL
     EGCSWLAHVK EALSTACLTA QGMEREGACI LVHGAEGTDS TLLVTSLAQL ILDPLSRTMV
     GFQELVEREW IQAGHPFQLR CAHSAFSHAR PKHEAPTFLL FLDCVWQLGR QFPLSLEFGE
     ALLLALFEHA YASPFGTFLC NSEKERCLCE VRSQTHSLWS RLNQPKEQRK LRNPLYVLNP
     LALWPSVEPQ SLQLWQGLFL RWTRPPEPPE VAWEKVWQIV
//