ID G3T2U4_LOXAF Unreviewed; 1462 AA.
AC G3T2U4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=FRAS1 related extracellular matrix 1 {ECO:0000313|Ensembl:ENSLAFP00000007518.4};
GN Name=FREM1 {ECO:0000313|Ensembl:ENSLAFP00000007518.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007518.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000007518.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007518.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000007518.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007518.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 9785.ENSLAFP00000007518; -.
DR Ensembl; ENSLAFT00000008958.4; ENSLAFP00000007518.4; ENSLAFG00000008954.4.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000156990; -.
DR HOGENOM; CLU_001041_0_0_1; -.
DR InParanoid; G3T2U4; -.
DR OMA; DEWHIAV; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0097094; P:craniofacial suture morphogenesis; IEA:Ensembl.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR45739:SF7; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 7.
DR Pfam; PF03160; Calx-beta; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF141072; CalX-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS51854; CSPG; 7.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT REPEAT 57..148
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 168..263
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 305..407
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 428..535
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 556..653
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 788..878
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 909..1007
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1343..1450
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 1191..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1462 AA; 164280 MW; 29DBAFF864DB9F7B CRC64;
SALQHAVNYM KVAYMPPMQD IGPHPQHVQF TFSISNQHGG ILHGICFNIT ILPVDNQVPE
VFTNPLRVAE GGQCVISTEH ILVSDADTKL DNIYLSLQRP PLHGRVELNG LPLNTGSTFS
WEDLHALKIR YQHDGSEVLQ DDILLEVTDG TNSAEFVLHI KVFPVNDEPP VLKADLIPMM
HCSEGEEVVI TSEYIFATDV DSDDSRLVFM IARKPQHGVV RKAGIITDQF SQGDVISRAV
TYKHTGGEIG LMPCFDTITL VVSDGQAGPF VNGCCYSGAH PSVPLHESFP VYDLNITVHP
VDNQPPSIAI GTMFVVDEGL SASVTINHLS ATDPDTAADD LEFVLVSSPQ FGYIENTLPS
AGFEKSNMGK SIASFQWKDM KALHVNYVQS KHLRIEPTAD QFMVYVTDGK RRSLEIPFHV
IINPTNDEAP DFIVQNITVR EGQMRELGSS VINAADLDIP KDSLLFTITH EPRHGLLING
VFSEGLPQYK QPANPDQKHH LVHNFSMELL KTGMRLLYVH DDSESLADDF TIQLSDGKYK
LVKTISVEVT PVNDQKPVLT KKAEIVMNMG ETRIISNAVL SATDEDSPRE KIYYLFERLP
QNGQLQLKIG RDWVPLYPGM KCTQEEVDLN MLRYTHTGAV DSQNKDSFTF YLWDGDNRSP
AFECHITIKD IGKGKFIILI NKSILYQKDP FGHLSIKVIV YPNRTTKFLF CLYVITSPPQ
YGQLSWSRPL QASDEWHIAV QTVCYILQAK ITKVPSWSKV KFLFIVSNGL RTKHGVFEVT
LETVDKALPV VTMNKGLRLI KGATGLLTPD LLQLTDPDTP LEKLTFLLAQ LPQHGQLFLR
GTALLHPNFT QQDVDSKNVA YRHSGGDSQI DQFTFTATDR TNQGFVVDGR VWEEPVSFTI
QVDQLDKMAP HITYLRSPSQ VGLLKNGCYG IYITSRVLKA SDPDTEDDQI IFKISQGPQH
GHLENTTTVG EFIHEKFSQK DLNSKTILYI INPSREVNSD VMEFQIMDPT GNSAPPQILE
LKWSHIEWSQ TDYEVCEDVG VFPLEITRTG FLMDSAFVSV KVNPVSATVG KDFTVTPSKL
IQFDPGMSTK MWNIAITYDG LEEDDEVFEV ILNSPVNAVL GTKTKAAVKI LDSKGGQCHR
SYHSNQNKHK AREKGIWHPL HRGSSSPTTS GSFHLERKPF VSSMRLAVTR GDSPRGFDST
DLSRMRLRPR GNGRTIHPSS VYRNGTDIIY NYHGTVSLKL EDDSSSTHKR KAKVSVISCP
QKTIKVAELP QADKVESTTD SHFPRQDQLP SFPKNCTLEL KGLFYFEESL QKLYQCNGTA
WKAWSPQTKE VEDKPCPAGW HHHSGYCHSL ITEQKRTWTA AAQACREEHL GSLVTVLTRQ
HMRWLWDISG RRPFWIGLND QVHAGYWEWI GGEPVTFTNW RKVTHQHSKP GKNCVLVHRQ
GKWQTKDCRQ GKPHSYICSR KL
//
