ID G3T408_LOXAF Unreviewed; 955 AA.
AC G3T408;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Thyroid hormone receptor associated protein 3 {ECO:0000313|Ensembl:ENSLAFP00000008045.2};
GN Name=THRAP3 {ECO:0000313|Ensembl:ENSLAFP00000008045.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008045.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000008045.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008045.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000008045.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008045.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BCLAF1/THRAP3 family.
CC {ECO:0000256|ARBA:ARBA00006481}.
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DR RefSeq; XP_003415546.1; XM_003415498.2.
DR AlphaFoldDB; G3T408; -.
DR STRING; 9785.ENSLAFP00000008045; -.
DR Ensembl; ENSLAFT00000009588.2; ENSLAFP00000008045.2; ENSLAFG00000009587.2.
DR GeneID; 100677478; -.
DR KEGG; lav:100677478; -.
DR CTD; 9967; -.
DR eggNOG; ENOG502QR38; Eukaryota.
DR GeneTree; ENSGT00950000183163; -.
DR HOGENOM; CLU_014485_1_0_1; -.
DR InParanoid; G3T408; -.
DR OMA; SHSYKVE; -.
DR OrthoDB; 5323286at2759; -.
DR TreeFam; TF335939; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0035145; C:exon-exon junction complex; IEA:Ensembl.
DR GO; GO:0016592; C:mediator complex; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:Ensembl.
DR GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0048255; P:mRNA stabilization; IEA:Ensembl.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0042753; P:positive regulation of circadian rhythm; IEA:Ensembl.
DR GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR InterPro; IPR029199; THRAP3_BCLAF1.
DR PANTHER; PTHR15268; THRAP3/BCLAF1; 1.
DR PANTHER; PTHR15268:SF16; THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF15440; THRAP3_BCLAF1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT REGION 1..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..49
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..139
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..776
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 108598 MW; C2A7C8EF2AB06372 CRC64;
MSKTNKSKSG SRSSRSRSGS RSRSRSFSKS RSRSRSVSRS RKRRLSSRSR SRSYSPAHNR
ERNHPRVYQN RDFRGHNRGY RRPYYFRGRN RGFYPWGQYN RGGYGNYRSN WQNYRQAYSP
RRGRSRSRSP KRRSPSPRSR SHSRNSDKSS SDRSRRSSSS RSSSNHSRVE SSKRKSTKEK
KSSSKDSRPS QAAGDNQGDE AKEQTFSGGT SQDTKASESS KPWSDATTYG AGSTSRASAA
SDMSPRERSP ALKSPLQSVV VRRRSPRPSP VPKPSPPLSN TSQMGSTLSS GAGYQAGTHQ
GQFDHGSGSL SPSKKSPVGK SPPATGSTYG SSQKEETAAS GGAAYTKRYL DEQKTENGKD
KEQKQTNTDK EKMKEKGSFS DTGLGDAKMK SDPFAPKTDA EKPFRGSQSP KRYKLRDDFE
KKMADFHKEE MDDQDKDKAK GRKESEFDDE PKFMSKVIAG VNKNQEEEKS GKWEGLVYAP
PGKEKQRKTE ELEEESFSER SKKEDRGGTK RTESGHRGFV PEKNFRVTAY KAVQEKSSSP
PPRKTSESRG KGDFSTGKSS FSITREAQVN VRMDSFDEDL ARPSGLLAQE RKLCRDLVHS
NKKEQEFRSI FQHIQSAQSQ RSPSELFAQH IVTIVHHVKE HHFGSSGMTL HERFTKYLKR
GTEQEAAKNK KSPEIHRRID ISPSTFRKHG LAHDEMKSPR EPGYKAEGKY KDDPVDLRLD
IERRKKHKER DLKRGKSRES VDSRDSSHSR ERSAEKTEKT HKGSKKQKKH RRARDRSRSS
SSSSQSSHSY KAEEYTEETE EREESTTGFD KSRLGTKDFV GPSERGGGRA RGTFQFRARG
RGWGRGNYSG NNNNNSNNDF QKRNREEEWD PEYTPKSKKY YLHDDREGEG SEKWVSRGRG
RGAFPRGRGR FMFRKSSTSP IWAHDKFSGE EGEIEDDESG TEIREEKDNL QPTTE
//
