ID G3T4H6_LOXAF Unreviewed; 440 AA.
AC G3T4H6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Transmembrane protease serine {ECO:0000256|PIRNR:PIRNR037941};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR037941};
GN Name=TMPRSS11E {ECO:0000313|Ensembl:ENSLAFP00000008261.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008261.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000008261.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008261.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000008261.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008261.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family.
CC {ECO:0000256|PIRNR:PIRNR037941}.
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DR AlphaFoldDB; G3T4H6; -.
DR STRING; 9785.ENSLAFP00000008261; -.
DR MEROPS; S01.021; -.
DR Ensembl; ENSLAFT00000009860.2; ENSLAFP00000008261.2; ENSLAFG00000009861.2.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000161786; -.
DR HOGENOM; CLU_006842_19_0_1; -.
DR InParanoid; G3T4H6; -.
DR OMA; HCFRTYK; -.
DR TreeFam; TF351684; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR017329; Pept_S1A_HAT/DESC1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF13; TRANSMEMBRANE SERINE PROTEASE 12; 1.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF037941; TMPRSS11ABCDE; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR037941, ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|PIRNR:PIRNR037941, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|PIRNR:PIRNR037941, ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Serine protease {ECO:0000256|PIRNR:PIRNR037941,
KW ECO:0000256|RuleBase:RU363034};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..184
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 209..439
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT ACT_SITE 249
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
FT ACT_SITE 294
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
FT ACT_SITE 390
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
SQ SEQUENCE 440 AA; 49965 MW; 59C6232C0347AD4F CRC64;
LNVIYSPEIS ALLKEWTCFL RPAVVRARKR TCLEPWAIGL ITFLSLIVLA VCIGLIVHYV
RYNQRNTHSY YSTLSFTSNR LYDEFGRETS KNFTEMSKKI ESMVKNAFCK SSLREEFVKS
QVIRFSQEDH GVLAHMLLIF RFRSTEDPEN ISKNIQRVLH EKLQNAVGHP KVDPESVEIK
KINKTETDNY LNSCCGTRRN KSISESLRIV GGTEAEEGEW PWQASLQWEE VHRCGATLIN
GTWLVSAAHC FRRYKDPGRW TASFGVTLMP PKMKRGLRRI IVHENYKYPS HDYDIAVAQL
SSPVPYTNVV HRICLPDASH EFHPGDHMFV TGFGALRNDG SSQNHLRQVQ VDLIDTKRCN
EPRAYNGAIT PRMLCAGSWQ GNKDACQGDS GGPLVSSNAR DIWYLAGIVS WGDECGQLNK
PGVYTRVTAF RDWIASTTGI
//
