ID G3T4I1_LOXAF Unreviewed; 624 AA.
AC G3T4I1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Spire type actin nucleation factor 2 {ECO:0000313|Ensembl:ENSLAFP00000008268.4};
GN Name=SPIRE2 {ECO:0000313|Ensembl:ENSLAFP00000008268.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008268.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000008268.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008268.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000008268.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008268.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm,
CC cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the spire family.
CC {ECO:0000256|ARBA:ARBA00010956}.
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DR AlphaFoldDB; G3T4I1; -.
DR STRING; 9785.ENSLAFP00000008268; -.
DR Ensembl; ENSLAFT00000009867.4; ENSLAFP00000008268.4; ENSLAFG00000009867.4.
DR eggNOG; ENOG502QQPN; Eukaryota.
DR GeneTree; ENSGT00390000003058; -.
DR HOGENOM; CLU_018839_1_1_1; -.
DR InParanoid; G3T4I1; -.
DR OMA; NTWTLNF; -.
DR TreeFam; TF326239; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0032154; C:cleavage furrow; IEA:Ensembl.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR GO; GO:0036089; P:cleavage furrow formation; IEA:Ensembl.
DR GO; GO:0051295; P:establishment of meiotic spindle localization; IEA:Ensembl.
DR GO; GO:0070649; P:formin-nucleated actin cable assembly; IEA:Ensembl.
DR GO; GO:0046907; P:intracellular transport; IEA:Ensembl.
DR GO; GO:0040038; P:polar body extrusion after meiotic divisions; IEA:Ensembl.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:Ensembl.
DR CDD; cd22186; WH2_Spire1-2_r3; 1.
DR CDD; cd22079; WH2_Spire2_r2; 1.
DR CDD; cd22081; WH2_Spire2_r4; 1.
DR CDD; cd22065; WH2_Spire_1-2_r1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR029901; Spire.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR PANTHER; PTHR21345:SF5; PROTEIN SPIRE HOMOLOG 2; 1.
DR PANTHER; PTHR21345; SPIRE; 1.
DR Pfam; PF16474; KIND; 1.
DR SMART; SM00750; KIND; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51377; KIND; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..122
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT REGION 53..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 70505 MW; F69457780EF95915 CRC64;
AEPTTMVVPP ASSEAQMVQS LGFAIYRALD WGLDESEERE LSPQLERLID LMANSDSDDG
GCGADEGYGG PEEEEETEGA PRAVRTFAQA MRLCAARLTE PRCAQAHYQA VCRALFLETL
ELRAFLARVR EAKEMLQKFR EDEPQAEKPL ADLNNLGHTD WTRLWVQLMR ELRHGVKLKK
VQERDFNPLP TEFQLTPFEM LMQDIRARNY KLRKVMVDGD IPPRVKKDAH EIILDFIRSR
PPLKQVSERR LRPLPEKQRT LHEKILEEIK QERKLRPVAS SPWDGRGFGS LPCIFNACAG
DVKSTSYINL STPDTKSSTQ RLRPRVLLKA PTLAELEEMT TSEEEESPCG ETMLKRDRSF
SEHDLAQLRS EVDSALPASE SSAARELPAR PRAGSVHAWR PNTEDHGSFP VSGQARPGPS
PPTLSSLGAV EERPEATAAL DNQAKHLWLE FSHPVESLAL TVEEVMDVRR VLVKAEMEKF
LQNRELYNNL KKGKICCCCR IKFPLFSWPP TCLFCKRAVC PSCSIKMKMP SKKFAHIPVY
TLGFECPPRV SSARTTTAQR KDVFQSLQGP QWRGVEEEFP HIYAHGCILK GVCSDCTSFV
AEVVRSSRKS VDVLNTTPRR ARQT
//
