GenomeNet

Database: UniProt
Entry: G3T4J8_LOXAF
LinkDB: G3T4J8_LOXAF
Original site: G3T4J8_LOXAF 
ID   G3T4J8_LOXAF            Unreviewed;       443 AA.
AC   G3T4J8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   31-JUL-2019, entry version 45.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000008291};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008291};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000008291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008291};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000008291}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008291};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   STRING; 9785.ENSLAFP00000008291; -.
DR   Ensembl; ENSLAFT00000009894; ENSLAFP00000008291; ENSLAFG00000009895.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00960000186595; -.
DR   InParanoid; G3T4J8; -.
DR   OMA; DCFMIGA; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003272; K_chnl_inward-rec_Kir2.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF14; PTHR11767:SF14; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   Pfam; PF08466; IRK_N; 1.
DR   PRINTS; PR01325; KIR22CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     89    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       10     53       IRK_N. {ECO:0000259|Pfam:PF08466}.
FT   DOMAIN       54    196       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      203    374       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      396    443       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   443 AA;  49547 MW;  0E9B95E64AA501CA CRC64;
     QGPPSPGMTA ASQANPYSIV SSEEDGLHLV TMSGANGFGN GKVHTRRRGR PRFVKKSGQC
     NIEFANMDEK SQRYLADMFT TCVDIRWRYM LLIFSLAFLA SWLLFGIIFW VIAVAHGDLE
     PAVAEGHGRT PCVLQVHGFM AAFLFSIETQ TTIGYGLRCV TEECPVAVFM VVAQSIVGCV
     IDSFMIGAIM AKMARPKKRA QTLLFSRHAV VALRDGKLCL MWRVGNLRKS HIVEAHVRAQ
     LIKPRVTEEG EYIPLDQIDI DVGFDKGLDR IFLVSPITIL HEIDEASPLF GLSRQDLETD
     DFEIVVILEG MVEATAMTTQ ARSSYLASEI LWGHCFEPVL FEEKNQYKID YAHFHKTYEV
     PSTPRCSAKD LVENKFLLPS AGSFCYENEL AFLSRDEEDE EGGDQDACSQ DGLSPQNRHE
     FDRLQAGGGS GLEQRPYRRE SEI
//
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