ID   G3T521_LOXAF            Unreviewed;       846 AA.
AC   G3T521;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Protein arginine methyltransferase 9 {ECO:0000313|Ensembl:ENSLAFP00000008498.3};
GN   Name=PRMT9 {ECO:0000313|Ensembl:ENSLAFP00000008498.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008498.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000008498.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008498.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000008498.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008498.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3T521; -.
DR   STRING; 9785.ENSLAFP00000008498; -.
DR   Ensembl; ENSLAFT00000010140.3; ENSLAFP00000008498.3; ENSLAFG00000010140.3.
DR   eggNOG; KOG1501; Eukaryota.
DR   GeneTree; ENSGT00940000158472; -.
DR   InParanoid; G3T521; -.
DR   OMA; NILEPFY; -.
DR   TreeFam; TF315221; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:Ensembl.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 2.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR   Pfam; PF06325; PrmA; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 2.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01015};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT   REPEAT          101..134
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   846 AA;  94227 MW;  41AD8286A1898053 CRC64;
     MPNSRLRPRR SAGSGGGAAG RDELVSRSLQ SAEHCLGAQD FGTAYAHYLL VLSLAPELKD
     DVKETFQYTL FKWAEELDAL GRIPDLLGCY EQALELFPDD EVICNSMGEH LFRMGFRDEA
     AGYFHKAVKL NPDFSDAKEN FYRVANWLVE RWHFIMLNDI RRNRIYNAAI QKAVRSGYKS
     VLDIGTGTGI LSIFAKKAGA HSVYACELSK TMYELACDVV AANKMEAGIK LLHMKSLDIE
     IPKHIPERVS LVVTETVDAG LFGEGIVESL IHAWDSLLLQ PKMQGDDGSC EKCGKVIPAS
     AVIFGVVVEC AEIRRHHRVG IKDIAGIHLP TSVKFQSPAY CPLDSEEALE PYTTEKMSRV
     PGGYLALTEH FEIMTVDFNN LQELKSLATK KPEKIGIPVS KEGTLDAVVV WFVLQLDDEH
     SLSTSPSEET CWEQAVYPVQ DLEDYRIKPG DHVTMEVSCQ DCYLRIQSIQ VLGLEHEMDV
     VKSFTKNEES PSLGNEAELC SALANLQTSK PDSVEQTCVL ESTEIALLNN IPYHEGFKTA
     MRKVLSALTP EKLLQAVGTR CQSEEVKSGS GQNENSLQSA RDPYYVLDVS EGFSILPIIA
     GSLGQVKPYS SVEKDQHRIA LDLISEANHF PKETLEFWLR HVEDESAMLQ RPKSDKLWSI
     IILDVIEPSG LIQQEIMEKA AISRCLLQSG GKIFPQYVVM LGLLVESQIL VEESAVQGTE
     CTLGVNIAPF INQFQVPIRV FLDLSSLPCI PLSEPVELLR LDLMTPYLNT SSREVKVHIC
     KSGQVTAIPF WYHVYLDEEI RLDTSSEASH WKQAAVVLDN PIQVEMGEEL VLSVQHHKSN
     VSITVK
//