ID   G3T580_LOXAF            Unreviewed;       518 AA.
AC   G3T580;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE   AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
GN   Name=INTS14 {ECO:0000313|Ensembl:ENSLAFP00000008573.2};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008573.2, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000008573.2, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008573.2,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000008573.2}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008573.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the INTS14 family.
CC       {ECO:0000256|ARBA:ARBA00007451}.
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DR   RefSeq; XP_010596351.1; XM_010598049.1.
DR   AlphaFoldDB; G3T580; -.
DR   STRING; 9785.ENSLAFP00000008573; -.
DR   Ensembl; ENSLAFT00000010235.2; ENSLAFP00000008573.2; ENSLAFG00000010235.2.
DR   GeneID; 100667056; -.
DR   KEGG; lav:100667056; -.
DR   CTD; 81556; -.
DR   eggNOG; ENOG502QQ37; Eukaryota.
DR   GeneTree; ENSGT00390000009486; -.
DR   HOGENOM; CLU_041485_0_0_1; -.
DR   InParanoid; G3T580; -.
DR   OMA; QSSVVWI; -.
DR   OrthoDB; 3673014at2759; -.
DR   TreeFam; TF323245; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR039841; INTS14.
DR   InterPro; IPR045814; IntS14_b-barrel.
DR   InterPro; IPR046471; IntS14_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR   PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR   Pfam; PF19435; IntS14_b-barrel; 1.
DR   Pfam; PF20504; IntS14_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          3..117
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|Pfam:PF13519"
FT   DOMAIN          209..356
FT                   /note="Integrator complex subunit 14 beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF19435"
FT   DOMAIN          404..511
FT                   /note="Integrator complex subunit 14 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20504"
SQ   SEQUENCE   518 AA;  57539 MW;  9A0F4805E7D3AFBF CRC64;
     MPTVVVMDVS LSMTRPVSVE GSEEYQRKHL AAHGLTMLFE HMATNYKLEF TALVVFSSLW
     ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALVGVCNIVQ QEWGGAIPCQ VVLVTDGCLG
     IGRGSLRHSL ATHNQRSENN RFPLPFPFPS KLYIMCMANL EELQSTDSLD CLERLIDLNN
     GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAVLKCGH LTADVQVFPR PEPFVVDEEI
     DPIPKVINTD LEIVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGTGIT DDNEDENSAN
     QIAGKIPNFC VLLHGSLKVE GMVAIVQLGP EWYGMLYSQA DSKKKSNLMM SLFEPGPEPL
     PWLGKMAQLG PISDAKENPY GEDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
     RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPDT AHPDAAFQLT
     HAAQQLKLAS TSTSEYAAYD HNITPLQTDF SGSSTERM
//