ID   G3T620_LOXAF            Unreviewed;       605 AA.
AC   G3T620;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=GTP-binding protein 1 {ECO:0000256|ARBA:ARBA00015364};
GN   Name=GTPBP1 {ECO:0000313|Ensembl:ENSLAFP00000008930.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008930.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000008930.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008930.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000008930.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008930.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Promotes degradation of target mRNA species. Plays a role in
CC       the regulation of circadian mRNA stability. Binds GTP and has GTPase
CC       activity. {ECO:0000256|ARBA:ARBA00025630}.
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DR   STRING; 9785.ENSLAFP00000008930; -.
DR   Ensembl; ENSLAFT00000010668.3; ENSLAFP00000008930.3; ENSLAFG00000010667.3.
DR   eggNOG; KOG0463; Eukaryota.
DR   GeneTree; ENSGT00940000156054; -.
DR   HOGENOM; CLU_012821_2_0_1; -.
DR   InParanoid; G3T620; -.
DR   OMA; CENDPAH; -.
DR   TreeFam; TF350446; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd03694; GTPBP_II; 1.
DR   CDD; cd03708; GTPBP_III; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR   PANTHER; PTHR43721:SF9; GTP-BINDING PROTEIN 1; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
PE   4: Predicted;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          210..320
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|Pfam:PF00009"
FT   REGION          508..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..531
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..578
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   605 AA;  66704 MW;  AB13CB8E188E116C CRC64;
     LVLVSPTSEQ YDSLLRQMWE RMDEGCGETI YVIGQGSDGT EYGLSEADME ASYATVKSMA
     EQIEADVILL RERQEAGGRV RDYLVRKRVG DNDFLEVRVA VVGNVDAGKS TLLGVLTHGE
     LDNGRFARQK TLRHKHEIES EHCQGVITDL LGWATERGLH GRSIRHIRXL VGLERCQEQG
     KIMIQLPLTM HFVFPDVWVF IFYCFHLSPD FVLRQVGSNA GIVGMTKEHL GLALALNVPV
     FVVVTKIDMC PANILQETLK LLQRLLKSPG CRKIPVLVQS KDDVIVMASN FSSERMCPIF
     QLSNVTGENL ELLKMFLNLL SPRTSYREEE PAEFQIDDTY SVPGVGTVVS GTTLRGLIKL
     NDTLLLGPDP LGNFLSIAVK SIHRKRMPVK EVRGGQTSFA LKKIKRSSIR KGMVMVSPRL
     NPQASWEFEA EILVLHHPTT ISPRYQAMVH CGSIRQTATI LSMDKDCLRT GDKATVHFRF
     IKTPEYLHID QRLVFREGRT KAVGTITKLL QTTNNSPMNS KPQQIKMQST KKGPLSRREE
     GGPAGGPSVG VPPPGDTATS LGAAQPSAAG SLQPQPKPSS GGRRRGGQRH KVKSQGACGT
     PASGC
//