ID G3T718_LOXAF Unreviewed; 208 AA.
AC G3T718;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Cell death-inducing p53-target protein 1 {ECO:0000256|ARBA:ARBA00040553};
DE AltName: Full=LITAF-like protein {ECO:0000256|ARBA:ARBA00041883};
GN Name=CDIP1 {ECO:0000313|Ensembl:ENSLAFP00000009367.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000009367.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000009367.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000009367.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000009367.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000009367.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the CDIP1/LITAF family.
CC {ECO:0000256|ARBA:ARBA00005975}.
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DR RefSeq; XP_003417783.1; XM_003417735.2.
DR RefSeq; XP_010595647.1; XM_010597345.1.
DR RefSeq; XP_010595648.1; XM_010597346.1.
DR RefSeq; XP_010595649.1; XM_010597347.1.
DR AlphaFoldDB; G3T718; -.
DR STRING; 9785.ENSLAFP00000009367; -.
DR Ensembl; ENSLAFT00000011196.2; ENSLAFP00000009367.2; ENSLAFG00000011197.2.
DR GeneID; 100661466; -.
DR KEGG; lav:100661466; -.
DR CTD; 29965; -.
DR eggNOG; ENOG502S2GM; Eukaryota.
DR GeneTree; ENSGT00940000157696; -.
DR HOGENOM; CLU_095549_0_0_1; -.
DR InParanoid; G3T718; -.
DR OMA; PHAPMGY; -.
DR OrthoDB; 1383925at2759; -.
DR TreeFam; TF313294; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0098560; C:cytoplasmic side of late endosome membrane; IEA:Ensembl.
DR GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR InterPro; IPR006629; LITAF.
DR InterPro; IPR037519; LITAF_fam.
DR PANTHER; PTHR23292:SF7; CELL DEATH-INDUCING P53-TARGET PROTEIN 1; 1.
DR PANTHER; PTHR23292; LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR; 1.
DR Pfam; PF10601; zf-LITAF-like; 1.
DR SMART; SM00714; LITAF; 1.
DR PROSITE; PS51837; LITAF; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 122..206
FT /note="LITAF"
FT /evidence="ECO:0000259|PROSITE:PS51837"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..67
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 208 AA; 21871 MW; 3F5719FF73290F71 CRC64;
MSNEPPPPYP GGPTAPLLEE KSGAPPNPGR ASPAVMQPPP GMPLPPADIG PPPYEPPSHP
VPQPGFVPQH VNPDGAYVPP GFYPPSGPHP PMGYYPPGPY PPGPFPGPGG HTATVLVPSG
AATTVTVLQG EIFEGAPVQT VCPHCQQAIT TKIAYEIGLM NFVLGFFCCF MGCDLGCCLI
PCLINDFKDV THTCPNCKAY IYTYKRLC
//
