ID G3T7T0_LOXAF Unreviewed; 759 AA.
AC G3T7T0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=von Willebrand factor A domain containing 2 {ECO:0000313|Ensembl:ENSLAFP00000009682.3};
GN Name=VWA2 {ECO:0000313|Ensembl:ENSLAFP00000009682.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000009682.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000009682.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000009682.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000009682.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000009682.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3T7T0; -.
DR STRING; 9785.ENSLAFP00000009682; -.
DR Ensembl; ENSLAFT00000011585.3; ENSLAFP00000009682.3; ENSLAFG00000011584.3.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000159040; -.
DR HOGENOM; CLU_008905_7_3_1; -.
DR InParanoid; G3T7T0; -.
DR OMA; MWCSAAM; -.
DR TreeFam; TF318242; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007161; P:calcium-independent cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0046626; P:regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd01472; vWA_collagen; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF37; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00092; VWA; 3.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00327; VWA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50234; VWFA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..759
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455071"
FT DOMAIN 50..221
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 295..332
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 342..516
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 530..704
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 711..747
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 737..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 759 AA; 82093 MW; 7310EB4A84178296 CRC64;
MCPFSLLLCV HVLSLLVPPS VPLQEVHVSR ETIGKISAAS KMMQCSAAVD ILFLLDGSHS
IGKRSFERSK HFAITVCDAL DVSPERVRVG AFQFSSAPQL EFPLDLFSTR QEVKAKIKTM
VFKGGSTETG LALKYLLCKG FPGGRNASVP QILIVVTDGK SQGQVALPAK QLKESGITVF
AVGVQFPRWE ELQVLASEPR EQHVLFAEQV EDATNGLFST LGSTAICTVA PPACRVEPHP
CERKMLETVR EHDGSAPCWR GSPRTNAVLA SRCPFYSWRR VFLSQPATCY RTTCPGACDS
QPCQNGGTCI LKGLDDYHCI CPLAFGGDAN CAPKLSLECR VDILFLLDSS AGTTLERFLQ
AKAFVKRFVQ SVLDEDSRAR VGVAHYSQEL VVAVPVGEYQ DVPGLLQSLD SIPFSGGATL
TGRALRQVAE RGFGSAARTG QDRPRKAVVL LTDARSQDKV AGLARRAWAQ ELLLLGVGSE
AVRAELEEIT GSPKHVMVYA DTQDLFRQIS ELQRKLCSQR GPGCQAQSLD LVFMLDASAS
VGPENFAHMQ SFMRSCTLQF DVNPDVTQVG LVVYGSQVQT AFGLDTHTTR AAVLRAMSQA
PYLGGMGSAG TAFLHIHDKV MTIQRGARPG VPKAVVVLTG GQGAEDAAVP AQKLRNNGIS
VLVVGVGPVL REALRRLAGP RDSLIHVAAY GDLKYHQDTL IDWICGETKR PVNLCKPSPC
MNEGTCVLQN GSYRCTCRDG WEGPHCGNRL LRGDAPKTR
//
