ID G3T9F2_LOXAF Unreviewed; 609 AA.
AC G3T9F2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A20 {ECO:0000313|Ensembl:ENSLAFP00000010408.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000010408.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000010408.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010408.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000010408.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010408.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR AlphaFoldDB; G3T9F2; -.
DR STRING; 9785.ENSLAFP00000010408; -.
DR Ensembl; ENSLAFT00000012455.4; ENSLAFP00000010408.4; ENSLAFG00000012456.4.
DR eggNOG; KOG3659; Eukaryota.
DR GeneTree; ENSGT00940000155873; -.
DR HOGENOM; CLU_006855_7_2_1; -.
DR InParanoid; G3T9F2; -.
DR OMA; FNNINHR; -.
DR TreeFam; TF343812; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0015193; F:L-proline transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005298; F:proline:sodium symporter activity; IEA:Ensembl.
DR GO; GO:1903804; P:glycine import across plasma membrane; IEA:Ensembl.
DR GO; GO:1904271; P:L-proline import across plasma membrane; IEA:Ensembl.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002438; Neutral_aa_SLC6.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF44; SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR PRINTS; PR01206; ORPHTRNSPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 25..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 68277 MW; 06111C74EA7A33E1 CRC64;
KRAPTYRARR PSTRSSGAME KTRPLWANPL QFVFACISYS VGLGNVWRFP YLCQMYGGGS
FLVPYIIMLI VEGMPLLYLE LAVGQRMRQG SIGAWRTISP YLSGVGVASV VVSFFLSMYY
NVINAWGFWY LFHSFQDPLP WSVCPLNSNH TGYDEECEKA TSTQYFWYRK TLNISPSIQE
NGGVQWEPAL CLILAWLMVY LCILRGTEST GKVVYFTALL PYCVLIIYLV RGLTLHGATN
GLAYMFTPKL EQLANPRAWI NAATQIFFSL GLGFGSLIAF ASYNEPSNNC QRHAIIVSLI
NSFTSIFASI VTFSIYGFKA TFNYENCLRK VILLLTNSFD LEDGFLTASN LEQVKTYLAS
TYPSKYSEVF PQIKNCSLES ELNTAVQGTG LAFIVYTEAI KNMEVSQLWS VLYFFMLLML
GIGSMLGNTA AILTPLTDSK VISSHLPKEA ISGLLCLISC AVGLVFTMDS GNYWFDIFND
YAATLSLLLI VLVETIAICY VYGLRRFESD LQSMTGRSLN WYWKVMWAGV SPLLIVSLFI
FYLSDYFLMG TLQYQAWDAS QGQLVTKDYP TYVLVFIGLL VASSTMCIPL VALGTFVMRH
QRGDTAPLA
//
