ID G3T9P0_LOXAF Unreviewed; 329 AA.
AC G3T9P0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=rRNA methyltransferase 1, mitochondrial {ECO:0000256|ARBA:ARBA00034881};
GN Name=MRM1 {ECO:0000313|Ensembl:ENSLAFP00000010519.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000010519.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000010519.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010519.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000010519.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010519.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR AlphaFoldDB; G3T9P0; -.
DR STRING; 9785.ENSLAFP00000010519; -.
DR Ensembl; ENSLAFT00000012582.4; ENSLAFP00000010519.4; ENSLAFG00000012584.4.
DR eggNOG; KOG0838; Eukaryota.
DR GeneTree; ENSGT00390000018761; -.
DR HOGENOM; CLU_021322_5_1_1; -.
DR InParanoid; G3T9P0; -.
DR OMA; QVPPYEY; -.
DR TreeFam; TF315167; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0070039; F:rRNA (guanosine-2'-O-)-methyltransferase activity; IEA:Ensembl.
DR CDD; cd18105; SpoU-like_MRM1; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR047182; MRM1.
DR InterPro; IPR047261; MRM1_MeTrfase_dom.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR46103; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46103:SF1; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 27..105
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 290..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 35859 MW; 1ED796FAC13C724B CRC64;
RPGGEELSRL RLDDLAVGRR SAGRLELLFG LSPCLLALRA ARRRVARLLL QAGRAGLQGE
RAELLRAAEE RGIPVVRPRR QKLDALSRHQ VHQGVCMEVS PLRLRPWTES GEARPGDDAQ
QLWLVLEGLQ DPRNLGAVLR SAHFLGVDKI IISRRNSCPL TPVVSKASAG AVEVMDVFST
DDLTGFMQAK ARQGWLVAGT VGCPGPEIPH SSQIPVISCL EFLWDRPTLL VLGNEGSGLS
QEVQASCQLL LTILPRRQLP PGLESLNVSV AAGILLHSIC SQRKGVAAER EREQLLQDPP
EFSTTFKEPR VAQHPGLSSG LEKERQNGG
//
