GenomeNet

Database: UniProt
Entry: G3TA15_LOXAF
LinkDB: G3TA15_LOXAF
Original site: G3TA15_LOXAF 
ID   G3TA15_LOXAF            Unreviewed;       418 AA.
AC   G3TA15;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=Transmembrane protease serine {ECO:0000256|PIRNR:PIRNR037941};
DE            EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR037941};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000010671.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000010671.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010671.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000010671.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010671.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|PIRNR:PIRNR037941}.
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DR   AlphaFoldDB; G3TA15; -.
DR   STRING; 9785.ENSLAFP00000010671; -.
DR   MEROPS; S01.207; -.
DR   Ensembl; ENSLAFT00000012762.3; ENSLAFP00000010671.3; ENSLAFG00000012761.3.
DR   eggNOG; KOG3627; Eukaryota.
DR   GeneTree; ENSGT00940000163621; -.
DR   HOGENOM; CLU_006842_19_0_1; -.
DR   InParanoid; G3TA15; -.
DR   OMA; RTYYYQG; -.
DR   TreeFam; TF351684; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.30.70.960; SEA domain; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR017329; Pept_S1A_HAT/DESC1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR   PANTHER; PTHR24253:SF29; TRANSMEMBRANE PROTEASE SERINE 11B-LIKE PROTEIN; 1.
DR   Pfam; PF01390; SEA; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PIRSF; PIRSF037941; TMPRSS11ABCDE; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF82671; SEA domain; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50024; SEA; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR037941, ECO:0000256|RuleBase:RU363034};
KW   Membrane {ECO:0000256|PIRNR:PIRNR037941, ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|PIRNR:PIRNR037941, ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Serine protease {ECO:0000256|PIRNR:PIRNR037941,
KW   ECO:0000256|RuleBase:RU363034};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          46..163
FT                   /note="SEA"
FT                   /evidence="ECO:0000259|PROSITE:PS50024"
FT   DOMAIN          187..417
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   ACT_SITE        227
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
FT   ACT_SITE        272
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
FT   ACT_SITE        368
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
SQ   SEQUENCE   418 AA;  47062 MW;  76EC710131296A30 CRC64;
     SFTCRPVTSS RTSLPLWMIA LIVFGVLAIL GITIGLLVHF LTTENRTYYY QGSFKVVDIP
     YNSNYERETS EETNRLSKIL ETKMMDAFQS SNIYRQYINS QVITLVPDNN SVTAHIWLVF
     KGSSSMKENT RRRIESILGQ MLRNHSESVT TDPNSLRLIE ISKVNAEKII NNRCGRRARM
     SATYDRVKGG STAQEGEWPW QASIQMNGKH YCGASLISDR YLVTAAHCFQ RTKNPKNYTV
     SFGTRVSPPY MEHYVQDIII HESYVPHEHH DDVAIVSLTE RVLFNNDVHR VCLPEASQIF
     PPGEGVVVTG WGALFYNGEY PALLQKAPVK IIDTNTCNAK EAYNGLVSDT MICAGYMEGN
     IDACQGDSGG PLVYPNSRNI WYLVGIVSWG SECGKINKPG VYMRVTSYSN WIASKTRV
//
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