ID G3TAH0_LOXAF Unreviewed; 739 AA.
AC G3TAH0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 08-NOV-2023, entry version 66.
DE SubName: Full=KRIT1 ankyrin repeat containing {ECO:0000313|Ensembl:ENSLAFP00000010867.3};
GN Name=KRIT1 {ECO:0000313|Ensembl:ENSLAFP00000010867.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000010867.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000010867.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010867.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000010867.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010867.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; G3TAH0; -.
DR STRING; 9785.ENSLAFP00000010867; -.
DR Ensembl; ENSLAFT00000012995.3; ENSLAFP00000010867.3; ENSLAFG00000012994.3.
DR eggNOG; KOG4335; Eukaryota.
DR GeneTree; ENSGT00530000063721; -.
DR InParanoid; G3TAH0; -.
DR OMA; FAIWIAS; -.
DR TreeFam; TF317921; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:Ensembl.
DR GO; GO:0033622; P:integrin activation; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13197; FERM_C_CCM1; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.30.70.2240; KRIT, N-terminal Nudix domain, NPxY motif-rich region; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041791; KRIT1_FERM_C.
DR InterPro; IPR032022; NUDIX.
DR InterPro; IPR043058; NUDIX_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR13283; KREV INTERACTION TRAPPED 1-RELATED; 1.
DR PANTHER; PTHR13283:SF11; KREV INTERACTION TRAPPED PROTEIN 1; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF16705; NUDIX_5; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00295; B41; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT REPEAT 357..380
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 423..739
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
SQ SEQUENCE 739 AA; 84667 MW; 4367DA65FE6F0126 CRC64;
MGNPENIEEA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLETKLQG
TGEITQGILD YVVETTKPIS PANQGIRGLG KRVVLMKTFP LDGEKMGREA ALFIVPSVVK
DNTKYTYTPG CPIFYCLQDI MRVCSESSTH FATLTARMLI ALDKWLDERH AQSHFIPALF
RPSPLERIKT NVINPAYTTE SGQTENSPLH MGYSALEIKS KMLALEKADT CIYNPLFGSD
LQYTNRVDKV VINPYFGLGA PDYSKIQIPK QEKWQRSMSS VTEDKERQWV DDFPLHRSAC
EGDSELLSRL LNERFSVNQL DSDHWAPIHY ACWYGKVEAT RILLEKGKCN PNLLNGQLSS
PLHFAAGGGH AEIVQILLNH PEVDRHITDQ QGRSPLNICE ENKQNNWEET VKLLKEAINK
PYEKVRIYRM DGSYRSVELK HGNNTTVQQI MEGMRLSQET QQYFTIWICS ENLSLQLKPY
HKPLQHVRDW PEILAELTNL DPQRETPQLF LRRDVRLPLE VEKKIEDPLA ILILFDEARY
NLLKGFYTAP DAKLITLASL LLQIVYGNYE SKKHKQGFLN EENLKSIVPI TKLKSKAPHW
TNRILHEYKN LSTSEGVSKE MHHLQRMFLQ NCWEIPTYGA AFFTGQIFTK ASPSNHKVIP
VYVGVNIKGL HLLNMETKAL LISLKYGCFM WQLGDADTCF QIHSMENKMS FIVHTKQAGL
VVKLLMKLNG QLMPTERNL
//