ID G3TAU4_LOXAF Unreviewed; 3511 AA.
AC G3TAU4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=WD repeat and FYVE domain containing 3 {ECO:0000313|Ensembl:ENSLAFP00000011029.3};
GN Name=WDFY3 {ECO:0000313|Ensembl:ENSLAFP00000011029.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011029.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011029.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011029.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011029.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011029.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9785.ENSLAFP00000011029; -.
DR Ensembl; ENSLAFT00000013177.3; ENSLAFP00000011029.3; ENSLAFG00000013162.3.
DR eggNOG; KOG1786; Eukaryota.
DR eggNOG; KOG1788; Eukaryota.
DR GeneTree; ENSGT00940000155680; -.
DR HOGENOM; CLU_000175_5_0_1; -.
DR InParanoid; G3TAU4; -.
DR OMA; GVCHLIE; -.
DR TreeFam; TF313658; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0034274; C:Atg12-Atg5-Atg16 complex; IEA:Ensembl.
DR GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016234; C:inclusion body; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035973; P:aggrephagy; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2514..2639
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2666..2961
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3108..3149
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3439..3499
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 2442..2505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3255..3299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2447..2461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3259..3274
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3280..3299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3511 AA; 393860 MW; 94BA09110CDC531C CRC64;
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA
SRGWMLLTTI NLLASSGQKT VDCMTTMSVP STLVKCLYLF FDLPHVPEAV GGAQNELPLA
ERRGLLQKVF VQILVKLCSF VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM
TISRHGLSVN VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL
LDDFRIWQGY NFLCDLLLRL EQAKEAESRD ALKDLVNLIT SLTTYGVSEL KPAGITTGAP
FLLPGFAVPQ PTGKGHSVRN VQAFAVLQNA FLKAKTNFLA QIILDAITNI YMADNANYFI
LEPQHTLSQF AEKISKLPEV QNKYFEMLEF IVFSLNYIPC KELISVSILL KSSSSYHCSI
IAMKTLLKFT RHDYIFKDVF REVGLLEVMV NLLHKYAALL KDPTQALSEQ GDSRNNSSVE
DQKHLALLVM ETLTLLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MIIQQLVLSP
NGDDDMGTLL GLMHSAPPTE LQLKTDILRA LLLVLRESHR SRTVFRKVGG FVYITSLLVA
MERSLSSPPK NGWEKVNQNQ VFELLHTVFC TLTAAMRYEP ANSHFFKTEI QYEKLADAVR
FLGCFSDLRK ISPMNVFPSN TQPFQRLLEE DVLSMDSVSP TLQHCSKLFI YLYKVATDSF
DSRAEQIPPC LTSESSLPSP WGTPALSRKR HAYHSVSTPP VYTPKNVADL KLHVAASSLQ
SSDAVVIHPG AMLAILDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL
HARLLQRCSA ALADEDHALH PPLQRMFERL ASQALEPMVL REFLRLASPL NCGAWDKKLL
KQYRVHKPSS LSYEPDMRSS MITSMEGLGS DNVFSLHEDN HYRISKSLVK SAEGSTVPLT
RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT SLEGFGCLFL PSLAPHNAPT NNAVTTGLTD
GAVVSGIGSG ERFFPPPSGL SYSSWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA
IVLSAKDRSL IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIVE GQWHHLVLVM
SKGMLKNSTA ALYIDGQLVN TVKLHYVHST PGGSGSANPP VVSTVYAYMG TPPAQRQIAS
LVWRLGPTHF LEEVLPPSNV TTIYELGPNY VGSFQAVCMP CKDAKSEGVI PSPVSLVPEE
KVSLGLYALS VYSLTVARIR KVYNKLDSKA IAKQLGISSH ENATPVKLIH NSAGHLNGPA
RTIGATLIGY LGVRTFVPKP VATTLQYIGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS
NPLASKEMER IKGYQSLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD
LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL LTLRDMSLSQ
PTIAAISNVL SFLLQGFPST NDLLRFGQFI SSTLPTFAVC EKFVVMEINH EEKLDTGTEE
EFGGLVSANL ILLRNRLLDI LLKLVYTSKE KTSINLQACE ELVRTLGFDW IMMFMEEHLH
STTVTAAMRI LVVLLSNQSI LIKFKEGLNG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR
STVREINRDA CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS
GRCKQGGQFD LDSIWTFIFG VPASSGTVVS SIHNVCTEAA FLLLGMLRSM LNSPWQSEEE
GSWLREYPVT LMQFFRYLYH NVPDLASMWM SPDFLCALAA TVFPFNIRPY SEMVTDLDDE
VGSPAEEFKA FVADTGMNRS QSEYCNVGTK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS
KQTPLIDLLL EASPERSTRT QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV
LVNNVFYFTQ RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL
YQFSRAHKTV PQQVALLDAL RVLTVNRTLI LGPGNHDQEF ISCLAHCLIN LHVGSNVDGF
GLEAEARMTT WHIMIPSDIE PDGGYSQDIS EGRQLLIKAV NRVWTELIHS KKQTLEELFK
VTLPVNERGH VDIAVARPLI EEASLKCWQN HLAHEKKCIS RGEALVPTTQ SKLSRVSSGF
GLSKLTGSRR NRKESGLSKH SLSTQEISQW MFTHVAVVRD LVDTQYKEYQ ERQQNALKYV
TEEWCQIEYE LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YNHYPYVPEA
EQETNVTKPA RYRRAVSYDS KEYYMRLASG NPAIVQDTIV ESSEGEATQQ EPEHGEDTIA
KVKGLVKPPL KRSRSAPDGG DEENQEQLQD QIAEGGSIEE EEKTDNATLL RLLEEGEKIQ
HMYRCARVQG LDTSEGLLLF GKEHFYVIDG FTMTATREIR DIETLPPNMH EPIIPRGARQ
GPSQLKRTCS IFAYEDIKEV HKRRYLLQPI AVEVFSGDGR NYLLAFQKGI RNKVYQRFLA
VVPSLTDSSE SVSGQRPNTS VEQGSGLLST LVGEKSVTQR WERGEISNFQ YLMHLNTLAG
RSYNDLMQYP VFPWILADYD SEEVDLTNPK TFRNLAKPMG AQTDERLAQY KKRFKDWEDP
NGETPAYHYG THYSSAMIVA SYLVRMEPFT QIFLRLQGGH FDLADRMFHS VREAWYSASK
HNMADVKELI PEFFYLPEFL FNSNNFDDCI GCKQNGTKLG DVILPPWAKG DPREFIRVHR
EALECDYVSA HLHEWIDLIF GYKQQGPAAV EAVNVFHHLF YEGQVDIYNI NDPLKETATI
GFINNFGQIP KQLFKKPHPP KRVRSRLNGD NAGICLPPGS TSDKIFFHHL DNLRPSLTPV
KELKEPVGQI VCTDKGILAV EQNKVLIPPA WNKTFAWGYA DLSCRLGTYE SDKAMTVYEC
LSEWGQILCA ICPNPKLVIT GGTSTVVCVW EMGTSKEKAK TLTLKQALLG HTDTVTCATA
SLAYHIIVSG SRDRTCIIWD LNKLSFLTQL RGHRAAVSAL CINELTGDIV SCAGTYIHVW
SINGNPIVSV NTFTGRSQQI VCCCVSEMNE WDTQNVIVTG HSDGVVRFWR MEFLQVPETP
APEPVEVLEM QEECPEAQIG QEAQDEDSSD SEAEEQSVSQ DPKEPPSQPS STIHRPRTAS
CQATATWFID SVSDDTRRWS DQLSLDEKDG FIFVNYSEGQ TRAHLQGPLN HPHSNPIEVR
NYSRLKPGYR WERQLVFRSK LTMHTAFDRK DNAHPAEITA LGISKDHSRI LVGDSRGRVF
SWSVSDQPGR SAADHWVKDE GGDSCSGCSV RFSLTERRHH CRNCGQLFCQ KCSRFQSEIK
RLKISSPVRV CQNCYYNLQH ERGSEDGPRN C
//
