ID G3TB37_LOXAF Unreviewed; 443 AA.
AC G3TB37;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Sorting nexin 27 {ECO:0000313|Ensembl:ENSLAFP00000011150.3};
GN Name=SNX27 {ECO:0000313|Ensembl:ENSLAFP00000011150.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011150.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011150.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011150.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011150.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011150.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TB37; -.
DR STRING; 9785.ENSLAFP00000011150; -.
DR Ensembl; ENSLAFT00000013323.3; ENSLAFP00000011150.3; ENSLAFG00000013322.3.
DR eggNOG; KOG3784; Eukaryota.
DR GeneTree; ENSGT00950000183212; -.
DR HOGENOM; CLU_028138_0_0_1; -.
DR InParanoid; G3TB37; -.
DR OMA; SGLHCTG; -.
DR TreeFam; TF318398; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0071203; C:WASH complex; IEA:Ensembl.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0032456; P:endocytic recycling; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13338; FERM-like_C_SNX27; 1.
DR CDD; cd01777; FERM_F1_SNX27; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd06886; PX_SNX27; 1.
DR Gene3D; 1.20.80.60; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR037831; SNX17/27/31-like.
DR InterPro; IPR037827; SNX27_FERM-like_dom.
DR InterPro; IPR037833; SNX27_PX.
DR InterPro; IPR037835; SNX27_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12431; SORTING NEXIN 17 AND 27; 1.
DR PANTHER; PTHR12431:SF19; SORTING NEXIN-27; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 1..38
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 63..171
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 175..264
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
SQ SEQUENCE 443 AA; 51744 MW; 0512DCC124BDE8A0 CRC64;
NEILERNGVN VEGATHKQVV DLIRAGEKEL ILTVLSVPPH EADNLDPSDD SLGQSFYDYT
EKQAVPISVP TYKHVEQNGE KFVVYNVYMA GRQLCSKRYR EFAILHQNLK REFANFTFPR
LPGKWPFSLS EQQLDARRRG LEEYLEKVCS IRVIGESDIM QEFLSESDEN YNGVSDVELR
VALPDGTTVT VRVKKNSTTD QVYQAIAAKV GMDSTTVNYF ALFEVINHSF VRKLAPNEFP
HKLYVQNYTS AVPGTCLTIR KWLFTTEEEI LLNDNDLAVT YFFHQAVDDV KKGYIKAEEK
SYQLQKLYEQ RKMVMYLNML RTCEGYNEII FPHCACDSRR KGHVITAISI TYFKLHACTE
EGQLENQVIA FEWDEMQRWD TDEEGMAFCF EYARGEKKPR WVKIFTPYFN YMHECFERVF
CELKWRKENI FQMARSQQRD VAT
//
