ID G3TBH4_LOXAF Unreviewed; 403 AA.
AC G3TBH4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Dynactin subunit 2 {ECO:0000256|ARBA:ARBA00034866};
GN Name=DCTN2 {ECO:0000313|Ensembl:ENSLAFP00000011328.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011328.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011328.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011328.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011328.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011328.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynactin subunit 2 family.
CC {ECO:0000256|ARBA:ARBA00006176}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010596593.1; XM_010598291.1.
DR AlphaFoldDB; G3TBH4; -.
DR STRING; 9785.ENSLAFP00000011328; -.
DR Ensembl; ENSLAFT00000013539.3; ENSLAFP00000011328.3; ENSLAFG00000013538.3.
DR GeneID; 100655036; -.
DR KEGG; lav:100655036; -.
DR CTD; 10540; -.
DR eggNOG; KOG3958; Eukaryota.
DR GeneTree; ENSGT00390000003427; -.
DR HOGENOM; CLU_049964_1_0_1; -.
DR InParanoid; G3TBH4; -.
DR OMA; RGYDMRG; -.
DR OrthoDB; 200040at2759; -.
DR TreeFam; TF105247; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005869; C:dynactin complex; IEA:Ensembl.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR InterPro; IPR028133; Dynamitin.
DR PANTHER; PTHR15346; DYNACTIN SUBUNIT; 1.
DR PANTHER; PTHR15346:SF0; DYNACTIN SUBUNIT 2; 1.
DR Pfam; PF04912; Dynamitin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 103..130
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 219..246
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 403 AA; 44548 MW; 2CD1FCB0B1F89937 CRC64;
MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK
RVGTKGLDFS DRIGKTKRTG YESGDYEMLG EGLGVKETPQ QKYQRLLHEV QELTTEVEKI
KTTVKESATE EKLTPVVLAK QLAALKQQLV ASHLEKLLGP DAAINLTDPD GALAKRLLLQ
LEATKNTKGT GSGGKTSNGA LPDSSLVTYE LHSRPEQDKF SQAAKVAELE KRLTELEATL
RCDQDTQNPL SAGLQGACLM ETVELLQAKV SALDLAVLDQ VEARLQSVLG KVNEIAKHKA
SVEDADTQSK VHQLYETIQR WSPIASTLPE LVQRLITIKQ LHEQAMQFGQ LLTHLDTTQQ
MIASSLKDNT TLLTQVQTTM RENLATVERN FASIDDRMKR LGK
//
