ID G3TBL8_LOXAF Unreviewed; 390 AA.
AC G3TBL8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Transmembrane protein 25 {ECO:0000313|Ensembl:ENSLAFP00000011380.3};
GN Name=TMEM25 {ECO:0000313|Ensembl:ENSLAFP00000011380.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011380.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011380.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011380.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011380.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011380.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TBL8; -.
DR STRING; 9785.ENSLAFP00000011380; -.
DR Ensembl; ENSLAFT00000013599.3; ENSLAFP00000011380.3; ENSLAFG00000013601.3.
DR eggNOG; KOG4555; Eukaryota.
DR GeneTree; ENSGT01080000257333; -.
DR HOGENOM; CLU_048525_0_0_1; -.
DR InParanoid; G3TBL8; -.
DR OMA; CVCLGRW; -.
DR TreeFam; TF333068; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090394; P:negative regulation of excitatory postsynaptic potential; IEA:Ensembl.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR042864; TMEM25.
DR PANTHER; PTHR47224; TRANSMEMBRANE PROTEIN 25; 1.
DR PANTHER; PTHR47224:SF1; TRANSMEMBRANE PROTEIN 25; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 260..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..148
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 325..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 42153 MW; BAEF45B46133AA9C CRC64;
AHPLLSAAWG PGWGHHGTAS RFCYRPAHTA APARPSELSP SQRPPAVFQV GGSWHQIDGQ
TWAERALREN ERHAFTCRVT GGHGTPQLAW YLDGQLQETS TSRLLTVGKE AFSRGTSTFT
VTAQRAQHEL NCSLQDLGSG RSANASVILN VQFKPEIAQV GAKYQEAQDP GLLVVLFALV
RANPPANVTW IDQDGPVTVN TTDFLVLDAQ NYPWLTNHTV QLQLRSLAHN LSVVATNDVG
VTTASLPAPG LLATRVEVPL LGIVVAGGLA LGALVGFSTL VACLVCRKER KTKGPSRRPS
LISSDSNNLK LSNVRLPREN MSLPSNLQLN DLTTDSRGKP ADRQMALNSS RPELLDPEPG
GLLTSRGFIR LPMLGYIYRV SSVSSDEIWL
//
