ID G3TC51_LOXAF Unreviewed; 489 AA.
AC G3TC51;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=DMRT like family A1 {ECO:0000313|Ensembl:ENSLAFP00000011607.3};
GN Name=DMRTA1 {ECO:0000313|Ensembl:ENSLAFP00000011607.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011607.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011607.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011607.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011607.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011607.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family.
CC {ECO:0000256|ARBA:ARBA00006834}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3TC51; -.
DR STRING; 9785.ENSLAFP00000011607; -.
DR Ensembl; ENSLAFT00000013860.3; ENSLAFP00000011607.3; ENSLAFG00000013860.3.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000160640; -.
DR HOGENOM; CLU_038477_1_0_1; -.
DR InParanoid; G3TC51; -.
DR OMA; ELQFMYT; -.
DR TreeFam; TF317837; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0060179; P:male mating behavior; IEA:Ensembl.
DR GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd14417; CUE_DMA_DMRTA1; 1.
DR Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR005173; DMA.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR046472; DMRT5_1_DMB_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR PANTHER; PTHR12322:SF71; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A1; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF03474; DMA; 1.
DR Pfam; PF20624; DMRT5_DMB; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00070}; Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT DOMAIN 83..130
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DNA_BIND 83..130
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 51611 MW; AE87EA4FDD0C1E87 CRC64;
MEQSQCGSSD HSGSGRPQLV PGLVAAVPPP PSPALPVSPG MPVPPAFLRP PSLFLRSGAC
PPAPGLERGM VAVGCGYPRT PKCARCRNHG VVSALKGHKR FCRWRDCACA KCTLIAERQR
VMAAQVALRR QQAQEESEAR GLQRLLYSGP AGPGTRTSRE GGGSEDPQAA GVPAVVAALG
LGALRQASGL ATPAFDVFQP DYPGEKQERK TSKCGLYQSG QEAAASKSHQ LSLGSSPKSN
GVLGKQNIRS SSSENTNKED NTLSPHPGEQ SGGDESPRSL SSSEVESGNE SEWTKDFTAP
RSHLPTVSSR QRDPLDILTK IFPSYRHSRL KGILQSCKGD VVQAIEQVLN GKEHKSDTRE
LASSGGSGPT AFQRAPNFNL AGIGFGALGN KSAFSPLQTT SASRGGDSHL YSLSPRLGIS
PLRVAYSSPG RGLSGFMSPY LTSGLVPALP FRPPLDYSFS GMLRDSSYLP SKDSVMGGGL
YSRLNQPHL
//
