ID G3TCC8_LOXAF Unreviewed; 492 AA.
AC G3TCC8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=GTP binding protein 3, mitochondrial {ECO:0000313|Ensembl:ENSLAFP00000011705.3};
GN Name=GTPBP3 {ECO:0000313|Ensembl:ENSLAFP00000011705.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011705.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011705.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011705.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011705.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011705.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. TrmE GTPase family.
CC {ECO:0000256|ARBA:ARBA00011043}.
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DR RefSeq; XP_003413077.1; XM_003413029.2.
DR AlphaFoldDB; G3TCC8; -.
DR STRING; 9785.ENSLAFP00000011705; -.
DR Ensembl; ENSLAFT00000013980.3; ENSLAFP00000011705.3; ENSLAFG00000013978.3.
DR GeneID; 100667599; -.
DR KEGG; lav:100667599; -.
DR CTD; 84705; -.
DR eggNOG; KOG1191; Eukaryota.
DR GeneTree; ENSGT00390000016851; -.
DR HOGENOM; CLU_019624_3_1_1; -.
DR InParanoid; G3TCC8; -.
DR OMA; PYETSQM; -.
DR OrthoDB; 5478664at2759; -.
DR TreeFam; TF313153; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006400; P:tRNA modification; IEA:InterPro.
DR CDD; cd04164; trmE; 1.
DR CDD; cd14858; TrmE_N; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.430; tRNA modification GTPase MnmE domain 2; 1.
DR HAMAP; MF_00379; GTPase_MnmE; 1.
DR InterPro; IPR031168; G_TrmE.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR018948; GTP-bd_TrmE_N.
DR InterPro; IPR004520; GTPase_MnmE.
DR InterPro; IPR027368; MnmE_dom2.
DR InterPro; IPR025867; MnmE_helical.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42714; TRNA MODIFICATION GTPASE GTPBP3; 1.
DR PANTHER; PTHR42714:SF2; TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF12631; MnmE_helical; 1.
DR Pfam; PF10396; TrmE_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF116878; TrmE connector domain; 1.
DR PROSITE; PS51709; G_TRME; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 249..416
FT /note="TrmE-type G"
FT /evidence="ECO:0000259|PROSITE:PS51709"
SQ SEQUENCE 492 AA; 52068 MW; 301CB171C62441D2 CRC64;
MWRGLWTLQA RAARGLLRLC SRHGSGVPAP GSGATIFALS SGQGRCGVAV IRTSGPASGP
ALRGLTAGRD LPPARSASLR LLSDPRSGEP LDRALVLWFP GPQSFTGEDC AEFHVHGGFA
VVSGVLQALG GVPGLRPAEA GEFTRRAFAR GKLSLTEVEG LADLIHAETE AQRRQALRQL
DGELGRLCHD WAETLTTALA HVEAYIDFSE DDNLEEDVLE RVDSSVRGLE AALGAHLRDA
RRGQRLRSGA HVVVAGPPNA GKSSLVNLLS RKPVSIVSPE PGTTRDVLET PVDLAGFPAL
LSDTAGLREG VGPVEQEGVR RARARLEQAD LILAVLDASD LTSPSSCNFL DSVVAHLATQ
STNESSQRLL LVLNKLDLLS SEGPGFSPDL PPHLLLSCLT GEGLESLLEA LRKELAALCG
DPSTGPPLLT RARHQHHLQA CLDALGHYKE ARDLALAAEG LRVARGHLAR LTGGGGTEEI
LDVIFRDFCV GK
//
