ID G3TDC6_LOXAF Unreviewed; 505 AA.
AC G3TDC6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Nitric oxide synthase trafficking {ECO:0000313|Ensembl:ENSLAFP00000012143.3};
GN Name=NOSTRIN {ECO:0000313|Ensembl:ENSLAFP00000012143.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012143.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012143.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012143.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012143.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012143.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003405857.1; XM_003405809.2.
DR AlphaFoldDB; G3TDC6; -.
DR STRING; 9785.ENSLAFP00000012143; -.
DR Ensembl; ENSLAFT00000014493.3; ENSLAFP00000012143.3; ENSLAFG00000014492.3.
DR GeneID; 100671153; -.
DR KEGG; lav:100671153; -.
DR CTD; 115677; -.
DR eggNOG; KOG4429; Eukaryota.
DR GeneTree; ENSGT00510000048120; -.
DR HOGENOM; CLU_027170_1_0_1; -.
DR InParanoid; G3TDC6; -.
DR OMA; YSAWCHV; -.
DR OrthoDB; 5400939at2759; -.
DR TreeFam; TF318059; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11823; SH3_Nostrin; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR035656; Nostrin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065:SF62; NOSTRIN, ISOFORM H; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..260
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 292..372
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 439..498
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 163..233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 299..376
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 505 AA; 57487 MW; 4BD1EB4D068E0681 CRC64;
MRDPLTDCSY NKVYKNLKEF SQNGENFCKQ ITSVLQQRAN LETSYAKGLQ KLAIKLSKVL
QSTKRNCLSI AWTWASEGMK SAADLHQKLG KAIQLEAIKP THQVLSMQEK KRKALDNEVE
KAANLVINNW NQQIKAKKKL MVSTKKHEAL FHLVESSKQS VTKKEKQKLL NKLKKSTENL
AKEEENYYQK NMAGYSTRLK WESTLENCYQ SFLELEKERI QLLCNNLNQY NQHISAFGQT
LTMCHTQINC AISKVDAEKD IQSLMEEAAI STTEKKSEFL LIDYFEEDPN NSMDKERRKS
SIKSKLLRLQ RDIEKASKDK EGLEQMLNAY SSNSSFSDGK NQKDTAALMD ETNLKLDLLQ
ANAYKLSSIL AELEQRPKPT HPCSTCIFKW KEKEQTHSYV KISRPFMMKR LENIVSKASS
GGQNNPSSSS YLASDVPQLS NGLCKALYSF QARQEDELNL EKGDIVAIHE KKGEGWWFGS
LNGKEGHFPA AYVEELPSNT GNAAT
//
