ID G3TDV8_LOXAF Unreviewed; 662 AA.
AC G3TDV8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=WD repeat-containing protein 48 {ECO:0000256|ARBA:ARBA00021209};
DE AltName: Full=USP1-associated factor 1 {ECO:0000256|ARBA:ARBA00031683};
GN Name=WDR48 {ECO:0000313|Ensembl:ENSLAFP00000012392.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012392.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012392.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012392.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012392.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012392.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR48 family.
CC {ECO:0000256|ARBA:ARBA00006917}.
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DR AlphaFoldDB; G3TDV8; -.
DR STRING; 9785.ENSLAFP00000012392; -.
DR Ensembl; ENSLAFT00000014800.2; ENSLAFP00000012392.2; ENSLAFG00000014800.2.
DR eggNOG; KOG0308; Eukaryota.
DR GeneTree; ENSGT00920000149157; -.
DR HOGENOM; CLU_014960_0_1_1; -.
DR InParanoid; G3TDV8; -.
DR OMA; ENDCFSA; -.
DR TreeFam; TF315205; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0035800; F:deubiquitinase activator activity; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:1902525; P:regulation of protein monoubiquitination; IEA:Ensembl.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0007338; P:single fertilization; IEA:Ensembl.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd17041; Ubl_WDR48; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR021772; WDR48/Bun107.
DR PANTHER; PTHR19862; WD REPEAT-CONTAINING PROTEIN 48; 1.
DR PANTHER; PTHR19862:SF14; WD REPEAT-CONTAINING PROTEIN 48; 1.
DR Pfam; PF11816; DUF3337; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 11..45
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 56..97
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 98..139
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 149..190
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 191..232
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 592..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 74413 MW; 0B44D859373231CB CRC64;
QVSYVIRDEV EKYNRNGVNA LQLDPALNRL FTAGRDSIIR IWSVNQHKQD PYIASMEHHT
DWVNDIVLCC NGKTLISASS DTTVKVWNAH KGFCMSTLRT HKDYVKALAY AKDKELVASA
GLDRQIFLWD VNTLTALTAS NNTVTTSSLS GNKDSIYSLA MNQLGTIIVS GSTEKVLRVW
DPRTCAKLMK LKGHTDNVKA LLLNRDGTQC LSGSSDGTIR LWSLGQQRCI ATYRVHDEGV
WALQVNDAFT HVYSGGRDRK IYCTDLRNPD IRVLICEEKA PVLEMELDRS ADPPPAIWVA
TTKSTVNKWT LKGIHNFRAS GDYDNDCTNP VTPLCTQPDQ VIKGGASIIQ CHILNDKRHI
LTKDTNNSVA YWDVLKACKV EDLGKVDFED EIKKRFKMVY VPNWFSVDLK TGMLTITLDE
SDCFAAWVSA KDAGFSSPDG SDPKLNLGGL LLQALLEYWP RTHANPMDEE ENEVNHVNGE
QENRVQKGNG YFQVPPHTPV IFGEAGGRTL FRLLCRDSGG ETESMLLNET VPQWVIDITV
DKNMPKFNKI PFYLQPHASS GAKTLKKDRL SASDMLQVRK VMEHVYEKII NLDNESQTTS
SSNNEKPGEQ EKEEDIAVLA EEKIELLCQD QVLDPNMDLR TVKHFVWKSG GDLTLHYRQK
ST
//
