ID G3TDW1_LOXAF Unreviewed; 914 AA.
AC G3TDW1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Pre-mRNA-splicing factor CWC22 homolog {ECO:0000256|ARBA:ARBA00040488};
DE AltName: Full=Nucampholin homolog {ECO:0000256|ARBA:ARBA00042174};
GN Name=CWC22 {ECO:0000313|Ensembl:ENSLAFP00000012395.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012395.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012395.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012395.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012395.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012395.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the CWC22 family.
CC {ECO:0000256|ARBA:ARBA00006856}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3TDW1; -.
DR Ensembl; ENSLAFT00000014803.4; ENSLAFP00000012395.4; ENSLAFG00000014802.4.
DR GeneTree; ENSGT00940000153458; -.
DR HOGENOM; CLU_006308_1_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR18034; CELL CYCLE CONTROL PROTEIN CWF22-RELATED; 1.
DR PANTHER; PTHR18034:SF3; PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG; 1.
DR Pfam; PF02847; MA3; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 454..570
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..435
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 106189 MW; C8FEB55165D9725B CRC64;
MKSSVAQIKH SSGHDRRENC NSHQRTSSPE ERYAEQERSP RERDYFNYSK SDNEHSRRGR
SYDSGMESRS RDREKRRERE RDTDRKRSRK SPSPGRRSPE PSVTQSSSAQ DEPTAKKKKD
ELDPLLTRTG GAYIPPAKLR MMQEQITDKS LAYQRMSWEA LKKSINGLIN KVNISNIGII
IQELLQENIV RGRGLLSRSV LQAQSASPIF THVYAALVAI INSKFPQIGE LILKRLILNF
RKGYRRNDKQ LCLTASKFVA HLINQNVAHE VLCLEMLTLL LERPTDDSVE VAIGFLKECG
LKLTEVSPRG INAIFERLRN ILHESEIDKR VQYMIEVMFA VRKDGFKDHP VILEGLDLVE
EDDQFTHMLP LEDDYNPEDV LNVFKMDPNF MENEEKYRAI KKEILDEGDS DSNTDRDVGS
SEEEEEEDEE GEEDEEGKGQ KVTIHDKTEI NLVSFRRTIY LAIQSSLDFE ECAHKLLKME
FPESQTKELC NMILDCCAQQ RTYEKFFGLL AGRFCMLKKE YMESFESIFK EQYDTIHRLE
TNKLRNVAKM FAHLLYTDSL PWSVLECIKL SEETTTSSSR IFVKIFFQEL CEYMGLPKLN
ARLKDETLQP FFEGLLPRDN PRNTRFAINF FTSIGLGGLT DELREHLKNT PKVIVAKKPD
VEQNKSSPSS SSSASSSSGS DSSDSDSDSS DNSSESSSEE NDSSSTSSHS SASVIFVFSS
KNIRKKAQGK TRSKEVNKLI RKQQTNDRKQ DERRPEQRHQ ETRTERERRS EKQRDQNSRD
PNWREATTKY TSDRGVPSER NSYSRVANDR DQEMYIDLEN KHGDPKKKRE ERRNSFSENE
KHRHRNKDSE NFRRKERSKS REKNSKHSGS RSDENRYQNG AERRWEKSSS YSEQSRESKK
NQDRRREKSP TRQK
//
