ID G3TEG8_LOXAF Unreviewed; 439 AA.
AC G3TEG8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Ammonium transporter Rh type C {ECO:0000256|ARBA:ARBA00041036};
DE AltName: Full=Rhesus blood group family type C glycoprotein {ECO:0000256|ARBA:ARBA00042618};
GN Name=RHCG {ECO:0000313|Ensembl:ENSLAFP00000012641.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012641.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012641.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012641.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012641.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012641.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526;
CC Evidence={ECO:0000256|ARBA:ARBA00036376};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74892;
CC Evidence={ECO:0000256|ARBA:ARBA00036376};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747,
CC ChEBI:CHEBI:28938; Evidence={ECO:0000256|ARBA:ARBA00036550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28748;
CC Evidence={ECO:0000256|ARBA:ARBA00036550};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28749;
CC Evidence={ECO:0000256|ARBA:ARBA00036550};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391,
CC ChEBI:CHEBI:59338; Evidence={ECO:0000256|ARBA:ARBA00036492};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74392;
CC Evidence={ECO:0000256|ARBA:ARBA00036492};
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000256|ARBA:ARBA00011036}.
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DR AlphaFoldDB; G3TEG8; -.
DR STRING; 9785.ENSLAFP00000012641; -.
DR Ensembl; ENSLAFT00000015096.3; ENSLAFP00000012641.3; ENSLAFG00000015094.3.
DR eggNOG; KOG3796; Eukaryota.
DR GeneTree; ENSGT00950000182844; -.
DR HOGENOM; CLU_021386_0_1_1; -.
DR InParanoid; G3TEG8; -.
DR OMA; GWFHSFK; -.
DR TreeFam; TF314450; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR GO; GO:0035379; F:carbon dioxide transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0006873; P:intracellular monoatomic ion homeostasis; IEA:Ensembl.
DR GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR GO; GO:0070634; P:transepithelial ammonium transport; IEA:Ensembl.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF30; AMMONIUM TRANSPORTER RH TYPE C; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..432
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
SQ SEQUENCE 439 AA; 48416 MW; F7834CD357A88135 CRC64;
MAWNTNLRWR LPLTCLLLEA AMVVLFGVFV RYDYEADPHW PEEKRHKNII SDSENDFYYR
YPSFQDVHVM IFVGFGFLMT FLQRYGFSAL GFTFLLAAFG IQWALLMQGW FHSFKDGYIR
IGVESLINAD FCVGSVCVAF GALLGKVSPI QLLIMTLFQV TLFTVNEFIL LNLLLVKDAG
GSMTIHTFGA YFGLTVAWIL YRPNLQQSKE RQSSVYYSDL FAMIGTLFLW LYWPSFNSAV
SNHGDAQHRA VINTYCSLAA CVLTSVALSS ALQKKGKLDM VHIQNATLAG GVAVGTAAEM
MLMPYGSIIV GSISGIISTL GFTYLTPFLE THLKIQDTCG IHNLHGIPGL IGGIVGAVTA
ASATSEVYGH EGLVHAFDLE GGKYNRTTQL QGSFQAAGIF VSLAMALVGG GIVGIILKLP
CWGQPPDENC FEDEIYWEV
//