ID G3TEU4_LOXAF Unreviewed; 572 AA.
AC G3TEU4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Suppressor of cytokine signaling 7 {ECO:0000313|Ensembl:ENSLAFP00000012797.3};
GN Name=SOCS7 {ECO:0000313|Ensembl:ENSLAFP00000012797.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012797.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012797.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012797.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012797.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012797.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; G3TEU4; -.
DR STRING; 9785.ENSLAFP00000012797; -.
DR Ensembl; ENSLAFT00000015278.3; ENSLAFP00000012797.3; ENSLAFG00000015279.3.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000156314; -.
DR HOGENOM; CLU_022661_0_0_1; -.
DR InParanoid; G3TEU4; -.
DR OMA; RGSCSTH; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF37; SUPPRESSOR OF CYTOKINE SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 391..500
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 495..545
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..96
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..192
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 62048 MW; DBB5ED919DECD066 CRC64;
RNVGRRQSSR REAAPEPGPS ELLCPHRCAL DPKSLPSGLA LERTWGPAAG LEAQLAALGL
GQPAGPGVKM VGAGCCPCPC PAQPPPPQPQ PPAATPQAGE DPTETSDALL VLEGLESEAE
SLETNSCSEE ELSSPGRGGG GGGRLLLQPP GPELPPVPFP LQDLVPRARL SRGEQPQQPL
PPPPPPGPLR PLAGPSRKGS LKIRLSRLFR TKSCNGGSGS GDGTGKRPSG ELAASAASLT
DMGGSAGREL DAGRKPRLTR TQSAFSPVSF SPLFTGETVS LVDVDISQRG LTSPHPPTPP
PPPRRSLSLL DDISGTLPTS VLVAPMGSSL QSFPLPPPPP PHAPDAFPRV APIRATESLH
SQPPQHLQCP LYRPDSSSFA ASLRELEKCG WYWGPMNWED AEMKLKGKPD GSFLVRDSSD
PRYILSLSFR SQGITHHTRM EHYRGTFSLW CHPKFEDRCQ SVVEFIKRAI MHSKNGKFLY
FLRSRVPGLP PTPVQLLYPV SRFSNVKSLQ HLCRFRIRQL VRIDHIPDLP LPKPLITYIR
KFYYYDPQEE VYLSLKEAQL ISKQKQEVEP ST
//
