ID G3TEY9_LOXAF Unreviewed; 717 AA.
AC G3TEY9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=SET and MYND domain-containing protein 4 {ECO:0000256|ARBA:ARBA00026173};
GN Name=SMYD4 {ECO:0000313|Ensembl:ENSLAFP00000012856.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012856.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012856.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012856.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012856.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012856.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3TEY9; -.
DR STRING; 9785.ENSLAFP00000012856; -.
DR Ensembl; ENSLAFT00000015347.3; ENSLAFP00000012856.3; ENSLAFG00000015349.3.
DR eggNOG; KOG2084; Eukaryota.
DR GeneTree; ENSGT00730000111079; -.
DR HOGENOM; CLU_021727_0_0_1; -.
DR InParanoid; G3TEY9; -.
DR OMA; FDCTCPA; -.
DR TreeFam; TF106441; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR CDD; cd10536; SET_SMYD4; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044421; SMYD4_SET.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR46165; SET AND MYND DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46165:SF2; SET AND MYND DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 150..489
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 213..252
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
SQ SEQUENCE 717 AA; 79487 MW; 01DB06A5F756B0B9 CRC64;
YTFNPSIVLQ GVSHSRPNTE AISLCYANRS AAFFHLGQYE TCLEDIIRAQ SHGYPERLQP
KMMLRKAECL VTLGRLQEAS QTISDLESKL AAKPTLAASH FEVLQRNLHR LKTKVQKKEN
LSETFPAALT KAFKDMDLME ESEQIPSASS SVSLCTDPLK GRHLIATKDI LPGELLVKEA
AFVSVLNPGE MPQLHHGLES KWNTRVTNGD LHCHCCLKHT LATVPCDQCS YAKYCSQECM
QQAWELYHTV ECPQGGLLLT LGIFCHIALR VTLLARFEDV GKVVRKLCGE IGNKDICLPE
SENMLKTLNY DLGENEENGK IVETPIPGCD INGKYENNYN AVFNLLPHTE NHSPEHKFLC
ALSVAALCRQ LEAASFWALK PGLKSSKPKT AVTHVLSPEL NIWGVVMLRH MLQLQCNAQA
ITTIQHTGSK ESIITESREI RLATGIFPVV SLLNHSCRPN TSVSFTSTVA TIRASQQIAK
GQEILHCYGP HESRMAVAER QQKLRSQYFF ECTCPACHKE PRATAGPRWA AFCCHSCRAV
MQGEDVLSCG NRSCTESVSR SHLVSRLQDL QQQVGMAQKL LRSGKLEQAV QQLLGCQHAA
ESFLPAEHTV VGEIDDHLAQ AYAALGDWEK SATHLQKSLQ VVEVRHGPSS IEMGRELFKL
AQIFFNGCAI PEALNTIQKA EKVLSVHCGP WSDEIEELQK MKSCLLNLLP IPVGPSG
//
