ID G3TF44_LOXAF Unreviewed; 265 AA.
AC G3TF44;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=SET domain-containing protein {ECO:0000259|PROSITE:PS50280};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012922.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012922.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012922.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012922.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012922.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3TF44; -.
DR STRING; 9785.ENSLAFP00000012922; -.
DR Ensembl; ENSLAFT00000015423.4; ENSLAFP00000012922.4; ENSLAFG00000015425.4.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; KOG2461; Eukaryota.
DR GeneTree; ENSGT00940000165655; -.
DR HOGENOM; CLU_064013_1_0_1; -.
DR InParanoid; G3TF44; -.
DR OMA; ITWINRE; -.
DR TreeFam; TF337915; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19193; PR-SET_PRDM7_9; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR048414; PDRM9-like_Znf-C2H2.
DR InterPro; IPR044417; PRDM7_9_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019041; SSXRD_motif.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16515:SF52; HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9; 1.
DR PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF09514; SSXRD; 1.
DR Pfam; PF21225; zf-C2H2_5; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 65..178
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 227..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 30297 MW; FA7474272CE3A8F3 CRC64;
MYSLRERKGL EYQEVGEPQN DDYLYCEKCQ NFFIDTCAVH GAPMFVKDSP VDRGHPNHSA
LTLPPGLRIG PSSIPEAGLR VWYEVSEQLL GLHFGPYKGQ VTEDEAANSG YSWLITKRRN
CYKYVDGKDE PWANQMRYVN CTRDKEEQNL VAFQYHRQIF YWTCRTIQPG CELLVSYGDN
YGQELGIKWG SRNVEKGLDV GFQIGEPKPE IHPCPSCTLA ISSQKFLGQH TKHSHPSPPF
PGTPERKHLQ PEDPRPGGRR QQHSD
//
