ID   G3TGH3_LOXAF            Unreviewed;       600 AA.
AC   G3TGH3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Melanophilin {ECO:0000313|Ensembl:ENSLAFP00000013576.2};
GN   Name=MLPH {ECO:0000313|Ensembl:ENSLAFP00000013576.2};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000013576.2, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000013576.2, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013576.2,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000013576.2}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013576.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3TGH3; -.
DR   Ensembl; ENSLAFT00000016176.2; ENSLAFP00000013576.2; ENSLAFG00000016172.2.
DR   eggNOG; ENOG502RJPZ; Eukaryota.
DR   GeneTree; ENSGT00950000183138; -.
DR   HOGENOM; CLU_025193_2_0_1; -.
DR   InParanoid; G3TGH3; -.
DR   OMA; EAQGWLC; -.
DR   TreeFam; TF331599; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0017022; F:myosin binding; IEA:Ensembl.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd15752; FYVE_SlaC2-a; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR041282; FYVE_2.
DR   InterPro; IPR037442; Melanophilin_FYVE-rel_dom.
DR   InterPro; IPR006788; Myrip/Melanophilin.
DR   InterPro; IPR010911; Rab_BD.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR14555:SF1; MELANOPHILIN; 1.
DR   PANTHER; PTHR14555; MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED; 1.
DR   Pfam; PF02318; FYVE_2; 1.
DR   Pfam; PF04698; Rab_eff_C; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS50916; RABBD; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          4..124
FT                   /note="RabBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50916"
FT   REGION          146..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          494..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..391
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        552..569
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   600 AA;  66412 MW;  93899CADC6F0F42C CRC64;
     MGKKLDLSKL TDEEAKHIWE VIQRDFDLRR KEEERLEGLK GKIKKESSKR ELLSDSAHLN
     ETHCAHCLQP YRLLVNSRRQ CLDCHLFTCK GCGSAHPREQ GWLCDPCHLA RVVKVGSLEW
     YYKHVRARFK RFGSAKVVRS LSWRLQAGDG PEQTPGENGG DSEQTDEDED VDAAGKPQSG
     GSKKKRLLAI HNLNLEDDSD DFTQSRHHAL HLSSVLTAVD GPQPLTDDPG ADETTLQDTV
     AVEADRGAPG SQPRPEEQRD GPSTARRHSF AELYPPGDTC GAALGEAATA GTSTNRRDQL
     LPQYLADVDT SDEDSVRAHR MATHHAKWRS QTPSESQLME LHKCCSSEEP FLAQSPWVVH
     SPREAEPLVT IVHTDTDLEE ETLRRKLEEM TSNVSDQGTS SEEEEGQDTS AESNRSASSG
     GLPGVAPKVS ATRRQRDRWD TELQGPQDHA PPTRTTDEAL SELEDRVAVA ASQVKQAESE
     VSDIKSRIAA LQAAGLTVRP SGKPRKKSNI PVFLPRLGKL DQSPKDPNPD PSSEVKVVPV
     LAVPHLLKRK FSHSPKSADS DEEPFDRKSA YRGSLTQRNP NGRKEKADHI FAKPVMAHQP
//