ID G3TGN2_LOXAF Unreviewed; 146 AA.
AC G3TGN2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Sperm surface protein Sp17 {ECO:0000256|ARBA:ARBA00014863};
DE AltName: Full=Sperm autoantigenic protein 17 {ECO:0000256|ARBA:ARBA00031837};
GN Name=SPA17 {ECO:0000313|Ensembl:ENSLAFP00000013651.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000013651.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000013651.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013651.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000013651.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013651.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sperm surface zona pellucida binding protein. Helps to bind
CC spermatozoa to the zona pellucida with high affinity. Might function in
CC binding zona pellucida and carbohydrates.
CC {ECO:0000256|ARBA:ARBA00025518}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; G3TGN2; -.
DR STRING; 9785.ENSLAFP00000013651; -.
DR Ensembl; ENSLAFT00000016262.2; ENSLAFP00000013651.2; ENSLAFG00000016264.2.
DR eggNOG; ENOG502S4R6; Eukaryota.
DR GeneTree; ENSGT00440000039164; -.
DR HOGENOM; CLU_115900_0_0_1; -.
DR InParanoid; G3TGN2; -.
DR OMA; NCESEKE; -.
DR TreeFam; TF332959; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0035686; C:sperm fibrous sheath; IEA:Ensembl.
DR GO; GO:0097228; C:sperm principal piece; IEA:Ensembl.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:InterPro.
DR CDD; cd12100; DD_CABYR_SP17; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR047579; DD_CABYR_SP17.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR012105; Sp17.
DR PANTHER; PTHR10699; NEUROMODULIN; 1.
DR PANTHER; PTHR10699:SF16; SPERM SURFACE PROTEIN SP17; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF02197; RIIa; 1.
DR PIRSF; PIRSF016533; Sp17; 1.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00394; RIIa; 1.
DR SUPFAM; SSF47391; Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 14..51
FT /note="RIIa"
FT /evidence="ECO:0000259|SMART:SM00394"
FT REGION 74..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 146 AA; 16845 MW; AA9B9AB4B63295B4 CRC64;
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFENLLEKR EKTNFDPAEW
GAKVDDRFYN NHAFQEEELP EKDVPENEKS QESVNEEETT VTVLEPSKED KEKMEFAAVK
IQAVFRGHLA RQAVKKMKLA ESAKEE
//
