ID G3TGU0_LOXAF Unreviewed; 431 AA.
AC G3TGU0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000013719.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000013719.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000013719.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013719.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000013719.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013719.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR AlphaFoldDB; G3TGU0; -.
DR STRING; 9785.ENSLAFP00000013719; -.
DR Ensembl; ENSLAFT00000016339.4; ENSLAFP00000013719.4; ENSLAFG00000016325.4.
DR eggNOG; KOG3599; Eukaryota.
DR GeneTree; ENSGT00940000162813; -.
DR HOGENOM; CLU_552718_0_0_1; -.
DR InParanoid; G3TGU0; -.
DR OMA; GQPRIRM; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF136; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 3; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..314
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 329..401
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 431 AA; 49786 MW; 3CBBCE9923ADE6B6 CRC64;
GLPRWLAYLC WLLLGITSLA SAFFTALYSL ELNKDQATSW VISLVLSVLQ NTFISQPVKV
LKTTFHPRLV LRTVHKRETL APLVPTHLSA LVQILFLTLL MTTIYSAKNS NRFYLHQAIQ
KSFSHHFSEI KLLKDFYPWA ICTLLPNLYG DYRGFITDGN SFLLGNVLLR QIRNADTALF
PRRVSPQEQM KASHQDQEDT ENYGVNWGPP DTNTTQSDSI WHYQSQETLC GYPIQGEFAT
YSGGGYVVRL GRNSSTALRV LQHLKQNHWL DQHTKSLFVE FVVFNANVNL FCVVTLILEC
SKLGAFFTSV RLDSLISLWT SKNSFAWPII SQVIYYLLVC YYTFIQGCRL KQQRWRFFSR
KRNILDTSII LISFVTLGLD MKRTSLHKKN LARYRHNRDG YYAIIMLNNQ TTLPCYRFVS
FYEAVKMNSA V
//
