ID G3TH05_LOXAF Unreviewed; 2042 AA.
AC G3TH05;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Dedicator of cytokinesis 10 {ECO:0000313|Ensembl:ENSLAFP00000013804.4};
GN Name=DOCK10 {ECO:0000313|Ensembl:ENSLAFP00000013804.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000013804.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000013804.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013804.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000013804.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000013804.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSLAFT00000016439.4; ENSLAFP00000013804.4; ENSLAFG00000016427.4.
DR GeneTree; ENSGT00940000157469; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 73..182
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 564..742
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1582..2042
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 41..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2042 AA; 233736 MW; 7406A551061F3EBC CRC64;
QACKFYSSQW HVVNYKYEQY SGDIRQLPRI RAEYKPEKLP SHSFEVDHED ADKDEDTTSH
SSSKGGGGAG GTGVFKSGWL YKGNFNSTVN NTVTVRSFKK RYFQLTQLPD NSYIMNFYKD
EKISKEPKGC IFLDSCTGVV QNNRLRKYAF ELKMNDLTYF VLAAETESDM DEWIHTLNRI
LQISPEGTLQ GRRSTELTDL GLDSLDNSTA CECTPEETES SESSLHPDFA KYLAETEETV
RMTRNMERLN LFSLDPDIDN LKLQKKDISE PESVVKPFEE KASKRIMIIC KALNLNLQGC
VTENENDPVT NIEPFFVSVA LYDLRDSRKI SADFHVDLNH TSVRQMISGV PMALENGNID
TLTPPQSEEP YIKGFPEEWL KFPKQAIFSV SNPHSEIVLV AKIEKVLMGN IASGAEPYIK
NPDSNKYAQK ILKSNKQFCS KLGKYRMPFA WAVRSIFKDN QGNVDSDSRF SPLYRQESSK
ISTEDLLKLV SDYRRADRVS KTQTIPGSLD IAVDNVPLEH PNCVTSSFIP VKPFNVMAQP
EPTVEVEEFV YDSSKYCRPY RVYKNQIYIY PKHLKYDSQK CFNKARNITV CVEFKNSDEE
GAKPVKCIYG KPGGPLFTSA AYTAVLHHSQ NPDFSDEVKI ELPTQLHEKH HVLFSFYHVT
CDINAKANAK KKEALETSVG YSWLPLKRHD QIASQEYNIP VATSLPPNYL SFQDSASGKH
STSDIKWVDG GKPLFKVSTF VVSTVNSQDP HVNTFFKECQ KREKDMSQSP TSNFIRSCKN
LLNVEKIHAI MSFLPIIFNQ LFKVLVQNEE DEISTPVTRV LTDIVAKCHE EQLDHSVQSY
IKFVFKTRTY KERTVHEELA KNVTGLLKSN DSTTVKHVLK HSWFFFAIIL KSMAQHLIDT
SKIQLSRAQR FPESYQHELD NLVMVLCDHV IWKYKDAVEE TRRANHSVAR FLKRCFTFMD
RGFVFKMVNN YTSMFSSGDL KTLSQYKFDF LQEVCQHEHF IPLCLPIRSA NIPDPLTPSE
SIQELHASDM PEYSVTNEFC RKHFLIGILL REVGFALQED QDIRHLALAV LKNLMAKHSF
DDRYREPEKQ AQIASLYMPL YGMLLDNMPR IYLKDLYPFA INTSNQGSRD DLSTNGGFQT
QTTMKHANSV DTSFSKDVLN SIAAFSSIAI STVNHADSRA SLASLDSNPS TNEKNSEKTD
NCEKIPRPLS LIGSTLRFDK LDQAETRSLL MCFLHIIKTI SEETLIAYWQ RAPSPEVSDF
FSILDVCLQN FRYLGKRNIV RKIAAAFKFV QSTQNNGTLK GSNPSCQTSG LLTQWMHATT
SHEGHKQHRS QTLPIIRGKN ALSNPKLLQM LDNTMTSNSN EIDIVHHVDT EANIATEVCL
TILDLLSLFT QIHQRQLQQS DCQNSMMKRV FDTYMLFFQV NQSAIALKHV FASLRLFVCK
FPSAFFQGPA DLCGLFCYEV LKCCNHRSRS TQMEASALLY FFMRKNFEFN KQKSIVRSHL
QLIKAVSQLI ADAGIGGSRF QHSLAITNNF ANGDKQMKNS NFPAEVKDLT KRIRTVLMAT
AQMKEHEKDP EMLVDLQYSL ANSYASTPEL RRTWLESMAK IHARNGDLSE AAMCYIHIAA
LIAEYLKRKG YWKMEKICTP SMLLEDAHPC DSHPLLTTPG GGSMFSMGWP AFLSITPNIK
EEGAMKEDSG MQDTPYNENI LVEQLYMCVE FLWKSERYEL IADVNKPIIA VFEKQRDFKK
LSDLYYDIHR SYLKVAEVVN SEKRLFGRYY RVAFYGQAVG FFDEEEGKEY IYKEPKLTGL
SEISQRLLKL YADKFGVDNV KIIQDSNKVN PKDLDPKYAY IQVTYVTPFF EEKELEDRKT
DFEMHHNINR FVFETPFTLS GKKHGGVEEQ CKRRTVLTTS HLFPYVKKRI QVISQSSTEL
NPIEVAIDEM SKKVSELNQL CTMEEVDMIR LQLKLQGSVS VKVNAGPMAY ARAFLEETNA
KKYPDNQVKL LKEIFRQFAD ACGQALDVNE RLIKEDQLEY QEELRSHYKD MLSELSSVMN
EQ
//