ID G3TI18_LOXAF Unreviewed; 1911 AA.
AC G3TI18;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Myosin-7 {ECO:0000256|ARBA:ARBA00039815};
DE AltName: Full=Myosin heavy chain 7 {ECO:0000256|ARBA:ARBA00041438};
DE AltName: Full=Myosin heavy chain slow isoform {ECO:0000256|ARBA:ARBA00043207};
DE AltName: Full=Myosin heavy chain, cardiac muscle beta isoform {ECO:0000256|ARBA:ARBA00041905};
GN Name=MYH7 {ECO:0000313|Ensembl:ENSLAFP00000014263.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014263.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014263.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014263.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014263.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014263.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity
CC essential for muscle contraction. Forms regular bipolar thick filaments
CC that, together with actin thin filaments, constitute the fundamental
CC contractile unit of skeletal and cardiac muscle.
CC {ECO:0000256|ARBA:ARBA00037090}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9785.ENSLAFP00000014263; -.
DR Ensembl; ENSLAFT00000017014.4; ENSLAFP00000014263.4; ENSLAFG00000017000.4.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000159432; -.
DR InParanoid; G3TI18; -.
DR OMA; DQLADNE; -.
DR TreeFam; TF314375; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032982; C:myosin filament; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:Ensembl.
DR GO; GO:0007512; P:adult heart development; IEA:Ensembl.
DR GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
DR GO; GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
DR GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
DR GO; GO:0030049; P:muscle filament sliding; IEA:Ensembl.
DR GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR GO; GO:0031449; P:regulation of slow-twitch skeletal muscle fiber contraction; IEA:Ensembl.
DR GO; GO:0002026; P:regulation of the force of heart contraction; IEA:Ensembl.
DR GO; GO:0014728; P:regulation of the force of skeletal muscle contraction; IEA:Ensembl.
DR GO; GO:0003009; P:skeletal muscle contraction; IEA:Ensembl.
DR GO; GO:0014883; P:transition between fast and slow fiber; IEA:Ensembl.
DR GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF1; MYOSIN-7; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 32..81
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 85..754
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 631..653
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1233..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1911 AA; 220449 MW; 25A8D85DFFB2FA2C CRC64;
MVDAEMAVFG AAAPFLRKSE KERLADQTRP FDLKKDVYVP DDKEEFVKAT IVSREGGKIT
AETERGKTVT VREDQVMQQN PPKFDKIEDM AMLTFLHEPA VLYNLKERYA SWMIYTYSGL
FCVTVNPYKW LPVYTAEVVA AYRGKKRISD CPPVRESGAG KTVNTKRVIQ YFAVIAAIGD
RKKEQTTGKG TLEDQIIEAN PALEAFGNAK TVRNDNSSRF GKFIRIHFGA TGKLASADIE
TYLLEKSRVI FQLKAERDYH IFYQILSNKK PELLDMLLIT NNPYDYAFIS QGETTVASIN
DAEELMATDN AFDVLGFTAE EKNSMYKLTG AIMHFGNMKF KLKQREEQAE PDGTEEADKS
AYLMGLNSAD LLKGLCHPRV KVGNEYVTKG QNVQQVVYAK GALAKAVYER MFNWMVMRIN
STLETKQPRQ YFIGVLDIAG FEIFDFNSFE QLCINFTNEK LQQFFNHHMF VLEQEEYKKE
GIEWEFIDFG MDLQACIDLI EKPMGIMSIL EEECMFPKAT DMTFKAKLFD NHLGKSSNFQ
KPRNIKGKPE AHFSLIHYAG TVDYNILGWL QKNKDPLNET VVALYQKSSL KMLSTLFANY
AGADAPIEKG KGKAKKGSSF QTVSALHREN LNKLMTNLRS THPHFVRCII PNETKTPGLI
DNPLVMHQLR CNGVLEGIRI CRKGFPNRIL YGDFRQRYRI LNPAAIPEGQ FIDSRKGAEK
LLGSLDIDHN QYKFGHTKVF FKAGLLGLLE EMRDERLSRI ITRIQAQSRG VLARMEFKKL
LERRDSLLII QWNIRAFMGV KNWPWMKLYF KIKPLLKSAE REKEMATMKE EFGRLKEALE
KSEARRKELE EKMVSLLQEK NDLQLQVQAE QDNLADAEER CDQLIKNKIQ LEAKVKEMTE
RLEDEEEMNA ELTAKKRKLE DECSELKRDI DDLELTLAKV EKEKHATENK VKNLTEEMAG
LDEIIAKLTK EKKALQEAHQ QTLDDLQAEE DKVNTLTKAK VKLEQQVDDL EGSLEQEKKV
RMDLERAKRK LEGDLKLTQE SIMDLENDKQ QLDERLKKKD FELNALNARI EDEQALGIQL
QKKLKELQAR IEELEEELEA ERTARAKVEK LRSDLSRELE EISERLEEAG GATSVQIEMN
KKREAEFQKM RRDLEEATLQ HEATAAALRK KHADSVAELG EQIDNLQRVK QKLEKEKSEF
KLELDDVTSN MEQIVKAKAN LEKMCRTLED QMNEHRSKAE ETQRSVNDLT SQRAKLQTEN
GELSRQLDEK EALISQLTRG KLTYTQQLED LKRQLEEEVK AKNALAHALQ SARHDCDLLR
EQYEEETEAK AELQRVLSKA NSEVAQWRTK YETDAIQRTE ELEEAKKKLA QRLQDAEEAV
EAVNAKCSSL EKTKHRLQNE IEDLMVDVER SNAAAAALDK KQRNFDKILA EWKQKYEESQ
SELESSQKEA RSLSTELFKL KNAYEESLEH LETFKRENKN LQEEISDLTE QLGSSGKTIH
ELEKVRKQLE AEKLELQSAL EEAEASLEHE EGKILRAQLE FNQIKAEIER KLAEKDEEME
QAKRNHLRVV DSLQTSLDAE TRSRNEALRV KKKMEGDLNE MEIQLSHANR MAAEAQKQAK
SLQSLLKDTQ IQLDDAVRAN DDLKENIAIV ERRNNLLQAE LEELRAVVEQ TERSRKLAEQ
ELIETSERVQ LLHSQNTSLI NQKKKMDADL SQLQTEVEEA VQECRNAEEK AKKAITDAAM
MAEELKKEQD TSAHLERMKK NMEQTIKDLQ HRLDEAEQIA LKGGKKQLQK LEARVRELEN
ELEVEQKRNA ESIKGMRKSE RRIKELTYQT EEDRKNLLRL QDLVDKLQLK VKAYKRQAEE
AEEQANTNLS KFRKVQHELD EAEERADIAE SQVNKLRAKS RDIGTKGLGE E
//
