ID G3TJ82_LOXAF Unreviewed; 466 AA.
AC G3TJ82;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Lamin B1 {ECO:0000313|Ensembl:ENSLAFP00000014773.2};
GN Name=LMNB1 {ECO:0000313|Ensembl:ENSLAFP00000014773.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014773.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014773.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014773.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014773.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014773.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer
CC on the nucleoplasmic side of the inner nuclear membrane, which is
CC thought to provide a framework for the nuclear envelope and may also
CC interact with chromatin. {ECO:0000256|ARBA:ARBA00037635}.
CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; G3TJ82; -.
DR STRING; 9785.ENSLAFP00000014773; -.
DR Ensembl; ENSLAFT00000017617.2; ENSLAFP00000014773.2; ENSLAFG00000017617.2.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00940000157199; -.
DR HOGENOM; CLU_012560_9_0_1; -.
DR InParanoid; G3TJ82; -.
DR OMA; IGQWAIK; -.
DR TreeFam; TF101181; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005638; C:lamin filament; IEA:Ensembl.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043274; F:phospholipase binding; IEA:Ensembl.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
DR GO; GO:0006998; P:nuclear envelope organization; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF3; LAMIN-B1; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 1..269
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 311..426
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 267..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2..251
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 273..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 53149 MW; D6CF456E0AE2D8A0 CRC64;
SYAKKESDLN GAQIKLREYE AALNSKDAAL ATALGDKKSL EGDLEDLKDQ IAQLEASLSA
AKKQLADETL LKVDLENRCQ SLTEDLEFRK NMYEEEINET RRKHETRLVE VDSGRQIEYE
YKLAQALHEM REQHDAQVKL YKEELEQTYH AKLENARLSS EMNTSSVNSA REELMESRMR
IESLSSQLSN LQKESRACLE RIQELEDLLA KERDNSRRML SDKEREMAEI RDQMQQQLND
YEQLLDVKLA LDMEISAYRK LLEGEEERLK LSPSPSSRVT VSRASSSRSV RTTRGKRKRV
DVEESEASSS VSISHSASAT GNICIEEIDV DGKFIRLKNT SEQDQPMGGW EMIRKIGDTS
VTYKYTSRYV LKAGQTVTVS AFSRHVQASY PAQGIWQLSN IMDTGWLQAL LESKTGHEVA
QRSTVFKTTI PEEEEEEEEA PEAVVEEELF HQQGTPRASN RSCAIM
//
