ID G3TJB4_LOXAF Unreviewed; 621 AA.
AC G3TJB4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Forkhead box J3 {ECO:0000313|Ensembl:ENSLAFP00000014813.3};
GN Name=FOXJ3 {ECO:0000313|Ensembl:ENSLAFP00000014813.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014813.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014813.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014813.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014813.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014813.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; G3TJB4; -.
DR STRING; 9785.ENSLAFP00000014813; -.
DR Ensembl; ENSLAFT00000017664.3; ENSLAFP00000014813.3; ENSLAFG00000017663.3.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000160362; -.
DR HOGENOM; CLU_030503_0_0_1; -.
DR InParanoid; G3TJB4; -.
DR TreeFam; TF333250; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd20024; FH_FOXJ2-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR045912; FOXJ2/3-like.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46078; FORKHEAD BOX PROTEIN J2 FAMILY MEMBER; 1.
DR PANTHER; PTHR46078:SF3; FORKHEAD BOX PROTEIN J3; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 78..173
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 78..173
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 41..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 68889 MW; C2FA5EA419BA0699 CRC64;
MGLYGQVCPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG TGISKKSVLL
DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT LSEIYQWICD NFPYYREAGS
GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS YWAIDTNPKE DALPTRPKKR ARSVERASTP
YSIDSDSLGM ECIISGSASP TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV
NLNSVGSVHS YTPVTSHPEP VAQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY
KSVFEQSLSQ QGLMSIPSEP SQQSHTSCSY QHSPSSTVSS HPHSNQSSLS NSHGTGLNTT
GSNSVAQVSL SHPQMHTQPS PHPPHRPHLP QHPQRPQHPA QHPQQHSQLQ SPHPQHPSPH
QHLQHHPNHQ HQSLTHQAPP PPQQYPCNSG VSSDWYATLD MLKESCRIAS SVNWSDVDLS
QFQGLMESMR QADLKNWSLD QVQFADLCSS LNQFFTQTGL IHSQSNVQQN VCHGAMHPTK
PSQHIGTGNL YIDSRQNLPP SVMPPPGYPH MPQTLSSPGT TIAGHHGAMN QQHMMPSQAF
QMRRSLPPDD IQDDFDWDSI V
//
