ID G3TJF5_LOXAF Unreviewed; 1055 AA.
AC G3TJF5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Desmoglein 1 {ECO:0000313|Ensembl:ENSLAFP00000014857.3};
GN Name=DSG1 {ECO:0000313|Ensembl:ENSLAFP00000014857.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014857.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014857.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014857.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014857.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014857.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|ARBA:ARBA00037034,
CC ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_003406389.1; XM_003406341.1.
DR AlphaFoldDB; G3TJF5; -.
DR STRING; 9785.ENSLAFP00000014857; -.
DR Ensembl; ENSLAFT00000017720.3; ENSLAFP00000014857.3; ENSLAFG00000017709.3.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT01030000234624; -.
DR HOGENOM; CLU_005284_0_0_1; -.
DR InParanoid; G3TJF5; -.
DR OMA; LRKVCMH; -.
DR TreeFam; TF331809; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045295; F:gamma-catenin binding; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 4.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF9; DESMOGLEIN-1; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 3.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR PRINTS; PR01819; DESMOGLEIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 4.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1055
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455429"
FT DOMAIN 70..157
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 158..269
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 270..385
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 386..487
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 491..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 113386 MW; 0B2FCDDA8F5FEAE0 CRC64;
MDWHFFRTAA VLFIFLVVVE VNSEFQIQVR DYNVKNGTIK WHSIRRQKRE WIKFAAAIRE
GEDNSKRNPI AKIHSDCAAN QQVTYRITGV GIDQPPYGIF VINQKTGEIN ITSIVDREVT
PFFIIYCRAL NSLGQDLERP LELRVRVLDI NDNPPIFSMS TFVGQIEENS NANTLVMILN
ATDADEPNNL NSKIAFKIIR QEPSDSPMFI INRYTGEIRT MNNFLDREQY SQYSLAVRGS
DRDGGIDGVS AECECSIKIL DVNDNIPYMQ QSSYSISIQE NALYSDLLQI TVIDLDEEYS
DNWIAVIFFV SGNEGNWFEI EMNERTNVGT LKVVKPLDYE AMQNVQLSIA VRNKAEFHHS
VMSQYKVTAT AVSVTVENVI EGPVFRPGSK TYVVNSKMGA NYRVGDFVAT DLDTGLPSTT
VRYVMGTNPG NLLAVNSRTG AITLVNQVTR EQYDMLGGKY QGTILSIDDA SQRTCTGTII
IVLEGSDWGG SGGTSTTTST GSSTGGGTDS GTGVRYTPTN YDTTSPSDRE NGHTPSINPL
RNPIDNVHFG PAGIGLLILG FLLLGLVPFL LTYCDCGGAA GDRAGFEPVP ECSDGAIHSW
GVEGPQPELR DLTTAVCVPQ PLPDNANIME CVDNTGVYTN EYCAREMQDL GGGERASGFE
VTSGVKTSGG PEICQEYSGT LRRNSMRECR EGGLNMNFME SYFCQKAYAY ADEDEGRPSN
DCLLIYDIEG VGSPAGSVGC CSFIGEDLDD SFLDTLGPKF KKLADISLGK GADSYPDLDP
SWPPEHTEPV CPQQGTEPTT GRYPPISPHF GTTTVISEST YPSGPGAQHP IPIPDPLGYG
NVTMTESYAT SGTLKPSVHL HDNRQASNVV VTERVLGPIS GADLHGMLDV PDLRDGSNVI
VTERVIAPSS SLPTSLIIPD PREASNVVVT ERVIRPTSGV TGTLGMHPEL SNAHNVIVTE
RVVSGSGIAG ISGTAGISGS SAGGGGLSAA GVSGGGIGLS SLGGGGGLSG SMGGTATIGH
VRNSSDHHFS QTLGSASPGT ARSRITKYST VQYTK
//
