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Database: UniProt
Entry: G3TKI9_LOXAF
LinkDB: G3TKI9_LOXAF
Original site: G3TKI9_LOXAF 
ID   G3TKI9_LOXAF            Unreviewed;      1500 AA.
AC   G3TKI9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-OCT-2019, entry version 61.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000015343};
GN   Name=ARHGAP35 {ECO:0000313|Ensembl:ENSLAFP00000015343};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015343};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000015343}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015343};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000015343}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015343};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   RefSeq; XP_003406766.1; XM_003406718.2.
DR   STRING; 9785.ENSLAFP00000015343; -.
DR   Ensembl; ENSLAFT00000018313; ENSLAFP00000015343; ENSLAFG00000018311.
DR   GeneID; 100667574; -.
DR   KEGG; lav:100667574; -.
DR   CTD; 2909; -.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   GeneTree; ENSGT00950000182819; -.
DR   InParanoid; G3TKI9; -.
DR   KO; K05732; -.
DR   OMA; WAPGSDG; -.
DR   OrthoDB; 110157at2759; -.
DR   TreeFam; TF324451; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN      270    327       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      368    422       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      429    483       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      485    550       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      592    767       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      783    947       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1250   1437       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION     1125   1147       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1178   1208       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1446   1500       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      413    440       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1125   1140       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1183   1197       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1453   1470       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1471   1487       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1500 AA;  170542 MW;  5407E9DC8AFE58C0 CRC64;
     MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF HLDHTSVLST
     SDFGGRVVNN DHFLYWGEVS RSLEDCVECK MHIVEQTEFI DDQTFQPHRS TALQPYIKRA
     AATKLASAEK LMYFCTDQLG LEQDFEQKQM PDGKLLVDGF LLGIDVSRGM NRNFDDQLKF
     VSNLYNQLAK TKKPIVVVLT KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF
     STLVQLIDKS RGKTKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKNHNE NWLSVSRKMQ
     ASPEYQDYVY LEGTQKAKKL FLQHIHRLKH EHIERRRKLY LAALPLAFEA LTPNLDEIDH
     LSCIKAKKLL ETKPEFLKWF VVLEETPWDT TSHIDNMENE RIPFDIMDTV PAEQLYEAHL
     EKLRNERKRA EMRRAFKENL ETSPFITPGK PWEEARSFIM NEDFYQWLEE SVYMDIYSKH
     QKQIIDRAKE GFQELLLEYS ELFYELELDA KPSKEKMGVI QDVLGEEQRF KALQKLQAER
     DALILKHIHF VYHPTKETCP SCPACADAKI EHLISSRFIR PSDRNQKNSL SDPNIDRINL
     VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS FQTPTFQPHG
     CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLVHLPLTL ILVNKRGDTS GESLHSLIQQ
     GQQIASKLQC VFLDPASAGI GYGRNINEKQ ISQVLKGLLD SKRNLNLVSS TASIKDLADV
     DLRIVMCLMC GDPFSVDDIL FPVLQSQTCK SSHCGSNNSV LLELPIGLHK KRIELSILSY
     HSSFSIRKSR LVHGYIVFYS AKRKASLAML RAFLCEVQDI IPVQLVALTD GAVDVLDNDL
     SREQLTEGEE IAQEIDGRFT SIPCSQPQHK LELFHPFFKD VVEKKNIIEA THMYDNAAEA
     CSTTEEVFNS PRAGSPLCNS NLQDSEEDIE PPSYSMFRED TSLPSLSKDH SKLSMELEGN
     DGLSFFMSNF ESKLNNKVPP PVRPKPPVHF EITKGDLSYL DQGHRDGQRK SVSSSTWLPL
     DGFDPSDYAE PMDAVVKPRN EEENIYSVPH DSTQGKIITI RNINKAQSNG SGNGSDSEMD
     TSSLERGRKV SIVSKPVLYR TRCTRLGRFA SYRTSFSVGS DDELGPIRKK EEDQASQGYK
     GDNAVIPYET DEDPRRRNIL RSLRRNTKKP KPKPRPSITK ATWESNYFGV PLTTVVTPEK
     PIPVFIERCI EYIEATGLST EGIYRVSGNK SEMESLQRQF DQDHNLDLAE KDFTVNTVAG
     AMKSFFSELP DPLVPYSMQI DLVEAHKIND REQKLHALKE VLKKFPKENH EVFKYVISHL
     NKVSHNNKVN LMTSENLSIC FWPTLMRPDF STMDALTATR TYQTIIELFI QQCPFFFYNR
     PISEPPGATP SSPSAVPATV PFLTSTPVTS QPSPPQSPPP TPQSPMQPLL PSQLQAEHTL
//
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