ID G3TL08_LOXAF Unreviewed; 409 AA.
AC G3TL08;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN Name=TRAF1 {ECO:0000313|Ensembl:ENSLAFP00000015543.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015543.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000015543.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015543.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000015543.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015543.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR AlphaFoldDB; G3TL08; -.
DR STRING; 9785.ENSLAFP00000015543; -.
DR Ensembl; ENSLAFT00000018541.3; ENSLAFP00000015543.3; ENSLAFG00000018541.3.
DR eggNOG; KOG0297; Eukaryota.
DR GeneTree; ENSGT00940000161076; -.
DR HOGENOM; CLU_021061_0_0_1; -.
DR InParanoid; G3TL08; -.
DR OMA; CIVETNA; -.
DR TreeFam; TF321154; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd03779; MATH_TRAF1; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR037306; TRAF1_MATH.
DR InterPro; IPR032070; TRAF_BIRC3-bd.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF96; TNF RECEPTOR-ASSOCIATED FACTOR 1; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR PIRSF; PIRSF015614; TRAF; 2.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR015614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|PIRNR:PIRNR015614}.
FT DOMAIN 259..405
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT REGION 42..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 180..249
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 409 AA; 45355 MW; 714688E49FDF819C CRC64;
SSPRPAPDEN EFPFGCPPTV CQDPSEPRAL CCATCLSENI RNSEDQSCPK CRGDDPHSGS
PGNLLSQEKD HPDVAEARVG CPFAGVGCSF KGSSKSVQEH EATSQASHLN LLLGFVKQWK
AQLGSTQESG PMALEQNLSD LQLKAAVEVA GNLEVDCYRA PCSEGQEELA LQHFMKEKLL
AELEEKLRVF ENIVAVLNKE VEASHLALAA SIHQSQLDCD RILSLEQRVV ELQQTLAQKD
QALGKLEQSL HLMEEASFDG TFLWKITNVT RRCHESACGK TISLFSPAFY TAKYGYKLCL
RLYLNGDGTG KRTHLSLFIV IMRGEYDALL PWPFRNKVTF MLLDQNNREH AIDAFRPDLT
SASFQRPQSE TNVASGCPLF FPLSRLQSPK HAYVKDDTMF LKCIVETSA
//
