ID G3TL44_LOXAF Unreviewed; 355 AA.
AC G3TL44;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=NFKB inhibitor beta {ECO:0000313|Ensembl:ENSLAFP00000015585.4};
GN Name=NFKBIB {ECO:0000313|Ensembl:ENSLAFP00000015585.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015585.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000015585.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015585.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000015585.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015585.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TL44; -.
DR STRING; 9785.ENSLAFP00000015585; -.
DR Ensembl; ENSLAFT00000018590.4; ENSLAFP00000015585.4; ENSLAFG00000018591.4.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000161595; -.
DR HOGENOM; CLU_000134_6_0_1; -.
DR InParanoid; G3TL44; -.
DR OMA; AEADEWC; -.
DR TreeFam; TF320166; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR47303; -; 1.
DR PANTHER; PTHR47303:SF1; NF-KAPPA-B INHIBITOR BETA; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT REPEAT 57..89
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 93..125
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 206..238
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 240..272
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 298..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 37371 MW; A5A0E3CAAF794B91 CRC64;
MAGVACLGKA ADADEWCDSG LGSLGPDAAV PGGPGLGAEL GPGLSWVPLV FGYVTEDGDT
ALHLAVIHQH EPFLDFLLSF AAGTEYLDLQ NDLGQTALHL ASILGEASTV EKLYIAGAGL
CVAERGGHTA LHLACRVGAH ACARVLLQPR PRRPRGALDT CHAQDPDHTP DTECASVALY
SDPGLEKEDE ENEDDWKLQL EAENYEGHTP LHVAVIHRDA EMVRLLREAG ADLNKPEPTC
GRSPLHLAVE AQAADVLELL LRGGADPAAR MYGGRTPLGS AALRPNPILA CLLRAHGAPE
PEDEDDKPGP CRSSSSSDSD CGDEGDEYDD IVVHSGRSQD QLPPTPASSP LPDDP
//
