ID G3TLC7_LOXAF Unreviewed; 1845 AA.
AC G3TLC7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=B-TFIID TATA-box binding protein associated factor 1 {ECO:0000313|Ensembl:ENSLAFP00000015688.3};
GN Name=BTAF1 {ECO:0000313|Ensembl:ENSLAFP00000015688.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015688.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000015688.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015688.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000015688.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015688.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9785.ENSLAFP00000015688; -.
DR Ensembl; ENSLAFT00000018713.3; ENSLAFP00000015688.3; ENSLAFG00000018710.3.
DR eggNOG; KOG0392; Eukaryota.
DR GeneTree; ENSGT00940000157500; -.
DR HOGENOM; CLU_000315_1_1_1; -.
DR InParanoid; G3TLC7; -.
DR OMA; WYSDIAC; -.
DR TreeFam; TF300546; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd17999; DEXHc_Mot1; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR044972; Mot1.
DR InterPro; IPR044078; Mot1_ATP-bd.
DR InterPro; IPR022707; Mot1_central_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR36498; TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172; 1.
DR PANTHER; PTHR36498:SF1; TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172; 1.
DR Pfam; PF12054; DUF3535; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1274..1449
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1632..1786
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 215..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1845 AA; 206591 MW; CFF9420F3E215776 CRC64;
RLDRLFILLD TGTTPVTRKA AAQQLGEVVK LHPHELNNLL SKVLIYLRST NWDTRIAAGQ
AVEAIVKNVP EWNPVPRIKQ EPTSESSMED SSTADRLNFD RFDICRLLQH GASLLGSAGA
EFEVQDEKSG EVDTKERIAR QRKLLQKKLG LNMGEAIGMS TEELFNDEDL DYTPTAAALV
NKQPTLQAAE LIDSEFRAGM SNRQKNKAKR MAKLFAKQRS RDTVETNEKS NDSTDGEPEE
KRRKIANVVI NQSANDSKVL IDNISDNSSL IEETNEWPLE SFCEELCNDL FNPSWEVRHG
AGTGLREILK AHGKSGGKMG DSTLEEMIQQ HQEWLEDLVI RLLCVFALDR FGDFVSDEVV
APVRETCAQT LGVVLKHMNE TGVHKTVDVL LKLLTQEQWE VRHGGLLGIK YALAVRQDVI
NTLLPKVLTR IIEGLQDLDD DVRAVAAASL VPVVESLVYL QTQKVPFIIN TLWDALLELD
DLTASTNSIM TLLSSLLTYP QVQQCSIQQS LTVLVPRVWP FLHHTISSVR RAALETLFTL
LSTQDQTSSC WLIPILPDML RHIFQFCVLE SSQEILDLIH KVWMELLSKA SVQYIVAAAC
PWMGAWLCLM MQPSHLPIDL NMLLEVKART KEKTGGKVRQ GQSQSKEVLQ EYIAGADTVM
EDPATRDFVV MRARMMAAKL LGALCCCICD PGVNMVTQEI KPAESLGQLL LFHLNSKSAL
QRISVALVIC EWAALQKECK AVTLAVQPRL LDILSEHLYY DEIAVPFTRM QNECKQLISS
LADAHIEVGN RVNHSVFTID QANDLVTTVF NEVTSSFDLN PQVLQQLDSK RQQVQMTVTE
TNQEWQLLQL RVHTFAACAV VSLQQLPDKL NPVIKPLMET IKKEENTLVQ NYAAQCIAKL
LQQCTTRTPC PNSKIIKNLC SSLCVDPYLT PCVTCPVPTQ SGQENSKGSS SEKDGMHHTV
TKHRGIITLY RHQKAAFAIT SRRGPTPKAV KAQIADLPAG SSGNILVELD EAQKPYLVQR
RGAEFALTTI VKHFGNEMAV KLPHLWEAMI GPLRNTIDIN NFDGKSLLEK GDGPAQELVN
SLQVFETAAT SMDSELHPLL VQHLPHLYMC LQYPSTAVRH MAARCVGVMS KIATMETMNI
FLEKVLPWLG AIDDNIKQEG AIEALACVME QLDVGIVPYI VLLVVPVLGR MSDQTDSVRF
MATQCFATLI RLMPLEAGIP DPPNMSEELI QLKAKERHFL EQLLDGKKLE NYKIPVPINA
ELRKYQQDGV NWLAFLNKYK LHGILCDDMG LGKTLQSICI LAGDHCHRAQ EYARSKLAEC
MPLPSLVVCP PTLTGHWVDE VGKFCSREYL NPLHYTGPPT ERIRLQHQVK RHNLIVASYD
VVRNDIDFFR NIKFNYCILD EGHVIKNGKT KLSKAVKQLT ANYRIILSGT PIQNNVLELW
SLFDFLMPGF LGTERQFAAR YGKPILASRD ARSSSREQEA GVLAMDALHR QVLPFLLRRM
KEDVLQDLPP KIIQDYYCTL SPLQVQLYED FAKSRAKCDV EETVSSAALS EETEKPKLKA
TGHVFQALQY LRKLCNHPAL VLTPQHPEFK STTEKLAAQN SSLHDIQHAP KLSALKQLLL
DCGLGNGSTS EGGTESVVAQ HRILIFCQLK SMLDIVEHDL LKPHLPSVTY LRLDGSIPPG
QRHSIVSRFN NDPSIDVLLL TTHVGGLGLN LTGADTVVFV EHDWNPMRDL QAMDRAHRIG
QKRVVNVYRL ITRGTLEEKI MGLQKFKMNI ANTVISQENS SLQSMGTDQL LDLFTLDKDG
KAEKADASAS GKASMKSILE NLSDLWDQEQ YDSEYSLENF MHSLK
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