ID G3TLD0_LOXAF Unreviewed; 714 AA.
AC G3TLD0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Cytoplasmic polyadenylation element binding protein 3 {ECO:0000313|Ensembl:ENSLAFP00000015691.3};
GN Name=CPEB3 {ECO:0000313|Ensembl:ENSLAFP00000015691.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015691.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000015691.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015691.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000015691.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015691.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RRM CPEB family.
CC {ECO:0000256|ARBA:ARBA00010347}.
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DR AlphaFoldDB; G3TLD0; -.
DR STRING; 9785.ENSLAFP00000015691; -.
DR Ensembl; ENSLAFT00000018716.3; ENSLAFP00000015691.3; ENSLAFG00000018716.3.
DR eggNOG; KOG0129; Eukaryota.
DR GeneTree; ENSGT00940000158949; -.
DR InParanoid; G3TLD0; -.
DR OMA; CWAAIHA; -.
DR TreeFam; TF317658; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR GO; GO:0008135; F:translation factor activity, RNA binding; IEA:Ensembl.
DR GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; IEA:Ensembl.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR GO; GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:Ensembl.
DR GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR CDD; cd19757; Bbox1; 1.
DR CDD; cd12724; RRM1_CPEB2_like; 1.
DR CDD; cd12726; RRM2_CPEB2_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.640.40; Cytoplasmic polyadenylation element-binding protein, ZZ domain; 1.
DR InterPro; IPR032296; CEBP_ZZ.
DR InterPro; IPR038446; CEBP_ZZ_sf.
DR InterPro; IPR034819; CPEB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR12566; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB; 1.
DR PANTHER; PTHR12566:SF7; CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 3; 1.
DR Pfam; PF16366; CEBP_ZZ; 1.
DR Pfam; PF16367; RRM_7; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 457..544
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 565..643
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..99
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..192
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 77894 MW; 462810FA647C10AC CRC64;
MQDDLLMDKS KTQPQPQQQR QQQQPQPEPS AAEVPSTPLS SETPKPEDSS AVPALSPAAA
PPAPNGPEKM QMESPLLPGL SFHQPPQQPP PPPQEPAAPG ASLSPSFGST WSTGTTNAVE
DSFFQGITPV NGTMLFQNFP HHVNPVFGGT FSPQIGLAQT QHHQQPPPPP APQPAQPAQP
PQPQPPQQRR SPASPSQAPY AQRSAAAAYG HQPIMTSKPS SSSAAAAAAA AAAASSASSS
WSTHQSVNAA WSAPSNPWGG LQAGRDPRRA VGVGVGVGVG VPSPLNPISP LKKPFSSNVI
APPKFPRAAP LTSKSWMEDN AFRTDNGNSL LPFQDRSRPY DTFNLHSLEN SLMDMIRTDH
EPLKGKHYPP SGPPMSFADI MWRNHFAGRM GINFHHPGTD NIMALNTRSY GRRRGRSSLF
PFEDAFLDDS HGDQSLSSGL SSPTRCQNGE RVERYSRKVF VGGLPPDIDE DEITASFRRF
GPLVVDWPHK AESKSYFPPK GYAFLLFQEE SSVQALIDAC LEEDGKLYLC VSSPTIKDKP
VQIRPWNLSD SDFVMDGSQP LDPRKTIFVG GVPRPLRAVE LAMIMDRLYG GVCYAGIDTD
PELKYPKGAG RVAFSNQQSY IAAISARFVQ LQHNDIDKRV EVKPYVLDDQ MCDECQGTRC
GGKFAPFFCA NVTCLQYYCE YCWASIHSRA GREFHKPLVK EGGDRPRHVP FRWS
//
