ID G3TLH6_LOXAF Unreviewed; 366 AA.
AC G3TLH6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015750.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000015750.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015750.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000015750.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015750.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TLH6; -.
DR STRING; 9785.ENSLAFP00000015750; -.
DR Ensembl; ENSLAFT00000020970.3; ENSLAFP00000015750.3; ENSLAFG00000020819.3.
DR eggNOG; ENOG502RVY2; Eukaryota.
DR GeneTree; ENSGT00940000163420; -.
DR HOGENOM; CLU_757712_0_0_1; -.
DR InParanoid; G3TLH6; -.
DR OMA; CETSLAX; -.
DR TreeFam; TF335627; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR042849; ARHGEF33.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46944; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR PANTHER; PTHR46944:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 179..354
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 42211 MW; 9C4CCF04041C037F CRC64;
MSMIQAITSK QEEMQQKIEQ LQQEKRRESR KVKAKKTQKE EHGSQAGPVP TQGSPFRSIN
IPEPILPTED FTNLLPSQAY EKAQESRSLH VGDSNVKGMM GPGLNPTTPE VEENLKPCLS
ADIQSKGHLP SGVWRQPKDS KEWGEEYVTK DHPDKLKEVG QGRHTSLENV LCETSLAAKR
QTVALELLES ERKYVINISL ILKIKATFQG SDGKRNSKER SLFPGSLRYL VQQHLDLLHA
LQERILKWPR QGVLGDLFLK LTNDENNFLD YYVAYLRDLP ECISLVHVVV LKEGDEEIKS
DIYTLFFHIV QRIPEYLIHL QNVLKFTEQE HPDYYLLLVC VQRLRVFISH YTLLFQCNED
LLIQKR
//
