ID G3TMJ0_LOXAF Unreviewed; 712 AA.
AC G3TMJ0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=YME1 like 1 ATPase {ECO:0000313|Ensembl:ENSLAFP00000016337.2};
GN Name=YME1L1 {ECO:0000313|Ensembl:ENSLAFP00000016337.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016337.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016337.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016337.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016337.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016337.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR AlphaFoldDB; G3TMJ0; -.
DR STRING; 9785.ENSLAFP00000016337; -.
DR MEROPS; M41.026; -.
DR Ensembl; ENSLAFT00000022843.2; ENSLAFP00000016337.2; ENSLAFG00000021743.2.
DR eggNOG; KOG0734; Eukaryota.
DR GeneTree; ENSGT00550000074836; -.
DR HOGENOM; CLU_000688_19_2_1; -.
DR InParanoid; G3TMJ0; -.
DR OMA; RCWPVYV; -.
DR TreeFam; TF105005; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:Ensembl.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0035694; P:mitochondrial protein catabolic process; IEA:Ensembl.
DR GO; GO:0034982; P:mitochondrial protein processing; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0034214; P:protein hexamerization; IEA:Ensembl.
DR GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IEA:Ensembl.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR23076:SF37; ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1; 1.
DR PANTHER; PTHR23076; METALLOPROTEASE M41 FTSH; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 310..447
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 712 AA; 79448 MW; E2753642469DDC38 CRC64;
MFSLSSTVQP QVTVPLSHLI NAFHSPKTIS ISVSASAAQN QHRDVATEHE PPSSEPVLNL
RDLGLSELKI GQLDQLVDNL LPGFFKGKKI PSHWHTSHVS AQSFFENKYG YFDIFSTLRS
SCLYRRHPRT LQSICSDLQY WPVYTVSGFK TLSRTRRLQS TSERLASQHI APSFVKGFLL
RDRGSDVESL DKLMKTKNIP EAHQDAFKTG FAEGFLKAQA LTQKTNDSLR RTRLFLLVLL
LLGIYGLLKN PFLSVRFRTT TGLDSAVDPV QMKNVTFEHV KGVEEAKQEL QEVVEFLKNP
QKFTVLGGKL PKGILLVGPP GTGKTLLARA VAGEADVPFY YASGSEFDEM FVGVGASRIR
NLFREAKANA PCVIFIDELD SVGGKRIESP MHPYSRQTIN QLLAEMDGFK PNEGVIIIGA
TNFPEALDNA LIRPGRFDMQ VTVPRPDVKG RTEILKWYLN KIKFDQSVDP EIIARGTVGF
SGAELENLVN QAALKAAVDG KEMVTMKELE FSKDKILMGP ERRSVEIDNK NKTITAYHES
GHAIIAYYTK DAMPINKATI MPRGPTLGHV SLLPENDRWN ETRAQLLAQM DVSMGGRVAE
ELIFGTDHIT TGASSDFDNA TKIAKRMVTK FGMSEKLGVM TYNDTGKLSP ETQSAIEQEI
RILLRDSYER AKHILKTHAK EHKNLAEALL TYETLDAKEI QIVLEGKKLE VR
//
