ID G3TMS5_LOXAF Unreviewed; 1876 AA.
AC G3TMS5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Plexin B1 {ECO:0000313|Ensembl:ENSLAFP00000016444.2};
GN Name=PLXNB1 {ECO:0000313|Ensembl:ENSLAFP00000016444.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016444.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016444.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016444.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016444.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016444.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR Ensembl; ENSLAFT00000021777.2; ENSLAFP00000016444.2; ENSLAFG00000022692.2.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd12793; RasGAP_plexin_B1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF36; PLEXIN-B1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 10..452
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1592..1649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1619..1649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1876 AA; 205952 MW; 654B06E8108F7317 CRC64;
ITPSSPLSLH IPHTLGPSSA LTCGRAAFTP NGTQLQHLAQ DPTSGTIYLG ATNSLFQLSP
GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQLTNNPNQL LLVSPGALVV CGSVHQGVCE
QRRLGQLGQL LLRPERPGDT QYVAANDPVV STVGLVAQDL AGDPLLFVGR GYTSRGVGGG
IPPHHNAGPA AFSYEETAKL AVGRLSEYSH HFVSAFARGA SAYFLFLRRD LQAQSRAFRP
YVSRVCLRDQ HYYSYVELPL ACQGGRYGLV QAAAAPPAVG RPPSAAAGAS GASALCAFPL
DEVDRLANRT RDACYTREGR AEDGAEVAYI EYDVNSDCAQ LPVDTLDAYP CGSDHTPSPM
ASRIPLEATP VLEWPGVQLT AVAVTMEDGH TIAFLGDSQG QLHRVYLGPG SDGQPYSTQT
IQLGSAVSRD LLDGAFEHLY VMTQSTLLKV PVASCAQHLD CASCLTQRDP YCGWCVLLGR
CSRRSECSRG QGPERWLWSF QPELSCLRVA TVSPANISRE ERREIFLSVP DLPPLQPEES
YSCHFGEHQS LAVLTSSGVK CHSPDPSESP ALPKGADHVS VSVELRFGTV VIAQASLSFY
DCVAVTELRL SAQCQACVSS RWGCNWCVWQ HLCTHKALCD AGPMVVSQQE EVGWGASACP
CVESVQGSML MPVLVERQVH LLGRNLRLFQ DSPGDTECVM ELEGREWCLQ LGTRNRSMTG
GVLSYEALQP ELRVELFLRR AGHLRIDSAD GLHVVLYDCF VGHGDCSRCQ TAMPQYGCVW
CEGERPRCVA QEACGEAEAV ATQCPAPLIH SVEPLTGPVD GGTRVTIRGS NLGQHVQDVQ
DTVRVAGVPC AVDVQEYEVS SSLVCITGLS GEEVKGPATV EVPGRGHGVS EHYFAYQNPE
VYSIFPARGP RAGGTCLTLH GSKLLTGHLE DIRVVVGDQL CHLLPEQQSE QLRCETSPHP
APATLPVAVW FGATERRLQH SQFQYTSDPN ITSAGPAKSF LSGGREIRVR GQNLDVVQTP
RIRVTVAPKA LQPGQGLGRR RRMILETACP PGASCGGQHF EEPCRVNSSQ LITCRTPALP
GLPESPWVQV EFVLDNLVFD FATLNSMPFS YEADPTLHPL NPEDPTTPFR HKPGSVFSVE
GENLDLAMSK EEVVAMIGDG PCMVKTLTRH HLYCEPPTEQ PLPQHHAFRE APDALPEFTV
QMGNLRFSLG RVQYDGESPM AFPVAAQVGL GVGTSLLALA VLIIVLMYRR KSKQALRDYK
KVQIQLENLE SSVRDRCKKE FTDLMTEMTD LTSDLLGSGI PFLDYKVYAE RVFFPGHQES
PLHRDLGVPE SRRPTVEQGL GQLSNLLNSK LFLTKFIHTL ESQRTFSARD RAYVASLLTV
ALHGKLEYFT DILRTLLSDL VAQYVAKNPK LMLRRTETVV EKLLTNWMSI CLYTFVRDSV
GEPLYMLFRG IKHQVDKGPV DSVTGKAKYT LNDNRLLRED VEYRPLTLNA LLAVGPGAGE
AQGMPVKVLD CDTISQAKEK MLEQLYKGVP LAQRPDPRTL DVEWRSGVAG HLILSDEDVT
SEVQGLWRRL NTLQHYKVPD GATVALVPVT GGPGKVVPDE DDELWGPGTG TPMLEDVDEG
GIRPWHLVKP SDEPEPPRPR RGSLRSGERE RAKAIPEIYL TRLLSMKGTL QKFVDDLFQV
ILSTSRPVPL AVKYFFDLLD EQAQQHGISD QDTVHIWKTN SLPLRFWINI IKNPQFVFDV
QTSDNMDAVL LVIAQTFMDA CTLADHKLGR DSPINKLLYA RDIPRYKQMV ERYYADIRQA
IPASDQEMNS ILAELSRNFS GDLGARVALH ELYKYINKYY DQIITALEED GTAQKMQLGY
RLQQIAAAVE NKVTDL
//