ID G3TNA7_LOXAF Unreviewed; 576 AA.
AC G3TNA7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Glycoprotein nmb {ECO:0000313|Ensembl:ENSLAFP00000016702.2};
GN Name=GPNMB {ECO:0000313|Ensembl:ENSLAFP00000016702.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016702.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016702.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016702.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016702.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016702.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR AlphaFoldDB; G3TNA7; -.
DR STRING; 9785.ENSLAFP00000016702; -.
DR Ensembl; ENSLAFT00000023037.2; ENSLAFP00000016702.2; ENSLAFG00000022142.2.
DR eggNOG; ENOG502QVWX; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_017264_1_0_1; -.
DR InParanoid; G3TNA7; -.
DR OMA; HGWRKWN; -.
DR TreeFam; TF334865; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0048018; F:receptor ligand activity; IEA:Ensembl.
DR GO; GO:0045545; F:syndecan binding; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
DR GO; GO:0001818; P:negative regulation of cytokine production; IEA:Ensembl.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Ensembl.
DR GO; GO:0034103; P:regulation of tissue remodeling; IEA:Ensembl.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR PANTHER; PTHR11861:SF11; TRANSMEMBRANE GLYCOPROTEIN NMB; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..576
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455571"
FT TRANSMEM 506..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 281..315
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 576 AA; 64220 MW; 94E441B59A673211 CRC64;
MECFHCFLGF LLLAARLPLD TAKRFHEVLS DERPSAYMRD HNQLSGWSSD ENDWNEKLYP
VWKQGDSRWK NSWKGGHLQA VLTSDSPALV GSNITFVVNL VFPRCQKEDA NGNIVYEKNC
RNDTGLTPDL YVYNWTAWTE DGDWGNDTNQ GHHNVFPDGK PFPYPSRWKK CKFVYLFHTL
GQYFQKLGQS SARVSINTAN VTLGPQLMEV AVFFRRGRTF VPIAKVKDLY VVTDQIPVFV
SMFQKNDRNS SDDIFLRGLP IIFNVQIHDP SHFLNESAIK YKWNFGDNTG LFVSNNHISN
HTYVLNGTFS LNLTVQAAVP GPCAPPSPRP PKPTSSLVKL SCPILPPCPC PGLVCPFSLL
CQAGDNPLEL SEIPDERCQI NRYGYFRGTI TIVERILEVN IVRMTVPQPE DSVMDFVVTC
EGTIPTEVCT IISDPTCQLA QNPVCEPVDV DNNCLLTVRR AFKGTGTYCL NLTLGDATSL
GLTSTLVSVP VPGKDPAFSL RMENGTLIAV GCLVIFVIVV TLMVYKKYKE YKPIENSPGK
AAKGKGLNSL FSRAKAAFSR GSQEKDPLLK NQPGII
//
