ID G3TNX9_LOXAF Unreviewed; 1455 AA.
AC G3TNX9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Mannose receptor C-type 1 {ECO:0000313|Ensembl:ENSLAFP00000017020.2};
GN Name=MRC1 {ECO:0000313|Ensembl:ENSLAFP00000017020.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017020.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000017020.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017020.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000017020.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017020.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSLAFT00000021691.2; ENSLAFP00000017020.2; ENSLAFG00000022148.2.
DR GeneTree; ENSGT01050000244842; -.
DR HOGENOM; CLU_002069_0_0_1; -.
DR InParanoid; G3TNX9; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00037; CLECT; 7.
DR CDD; cd00062; FN2; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 8.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR22803:SF124; C-TYPE LECTIN DOMAIN FAMILY 19 MEMBER A-RELATED; 1.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF00040; fn2; 1.
DR Pfam; PF00059; Lectin_C; 8.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00034; CLECT; 8.
DR SMART; SM00059; FN2; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 8.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 6.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 8.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1455
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455269"
FT TRANSMEM 1387..1410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..211
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 230..341
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 369..487
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 511..626
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 655..778
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 807..923
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 951..1079
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1101..1212
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1240..1355
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DISULFID 168..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 182..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 1455 AA; 165716 MW; 648476629C08A4ED CRC64;
LRLPVLLVFL SLVQVAVQLL DTRQFLIYNE DHKRCVEALS PSAVQTAACN PDNESQKFRW
VSDSQVMSVA FKLCLGVPSK TDWVAITLYA CDSKNEFQKW ECKNDTLFGI KGEDLFFNYG
NRQEKNIMLY KGSGLWSRWK IYGTTDDLCS RSYEAMFTLL GNANGATCAF PFKFENKWYA
DCTSVGRSDG WLWCGTTTDY DTDKLFGFCP LKFEGSESLW NKDPLTSIYY QINSKSALTW
HQARKSCQQQ SAELLSITEI HEQTYLTGLT SSLTSGLWIG LNSLSFNSGW QWSEGSPFRY
LNWLPGSPST EPGKSCVSLN PGKNAKWENL ECVQKLGYIC KKGNTTLNPF VIPSERDVPT
SCPSQWWPYA GHCYKIYRGE KKIQRNALTA CRKEGGDLAS IHSIEEFDFI FSQLGYESND
ELWIGLNDIK IQMYFEWSDG TPVTFTKWLH GEPSHENNRQ EDCVVMKGKD GHWADRACEQ
PLDYICKMKA QTQVPAIVEV ETGCRKGWKR HGFFCYLIGH TLSTFTEANQ TCGNEKAYLT
TVEDRYEQAF LTSFVGLRPE RYFWTGLSDI QSKGTFQWTI EEGVQFTHWN ADMPGRKAGC
VAMRTGIAGG LWDVLKCDEK AKFVCKHWAE GATRPPEPTT TPEPKCPEDW GTTSKSSLCF
KLFTKGKHDK KTWFESRDFC RALGGDLASI NNKEEQQAIW RLITSSSSYH ELFWLGLTYG
SPSEGFTWSD GSPVSYEHWA YGEPNNYQNV EFCGELKGDP GMFWNDINCE HLNNWICQIK
KGQTPKPEPT PAPQDNPPVT EDGWVIYKEY QYYFSKEKET MDNAREFCKR NFGDLVSIQS
ESEKKFLWKY VNRNDAQSAY FIGLLISLDK KFIWVDGSKV DYVAWATGEP NFANDDENCV
AMYSNSGFWN DINCGYPHAF ICQRHNSSIN ATVLPTTPPV KGGCEQGWKS YNNKCFKIFG
FVEEERKNWQ EARKACIGFG GNLVSIRNEK EQAFLTYQMT GSSFNAWIGL NDVNSEHTFL
WTDQRGVYYT NWGKGYPGGR RSSLSYEDAD CVVIIGGKSQ DAGKWMDDTC DSKRGYICHT
LPNPSLPVSP TTVPSDGFIN FGESSYSLID LKLSWYEAEK YCTLHNSHIG SILDPYSNAF
VWIQMEKLNS PVWIALNSNL TNNEYVWTDK WRVRYTNWAA DEPKLKSACV YLDTDGYWKT
AYCNESFYSL CKRSNDTPAT EPPQLPGRCP ESDHTAWIPF HGHCYYIESS YTKNWGHASL
ECLRMGSSLV SIESAAESSF LSYRVEPLKS KTNFWIGLFR NVEGMWLWIN KNPVSFVNWN
AGDPSGERND CVTLLASSGF WNNVHCSSYK GYICKRPKIV DAEPTRTLMT TKADSRKMDP
SKPSSSVAGI VVIVILLILT GTGLAAYFFY KKRRVQLPQE STFENTLYFN SRSSPGTNDT
KDLMDNIEQN ERAAI
//
