ID G3TP23_LOXAF Unreviewed; 503 AA.
AC G3TP23;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=T-box transcription factor 1 {ECO:0000313|Ensembl:ENSLAFP00000017085.2};
GN Name=TBX1 {ECO:0000313|Ensembl:ENSLAFP00000017085.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017085.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000017085.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017085.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000017085.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017085.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; G3TP23; -.
DR STRING; 9785.ENSLAFP00000017085; -.
DR Ensembl; ENSLAFT00000022669.2; ENSLAFP00000017085.2; ENSLAFG00000021555.2.
DR eggNOG; KOG3586; Eukaryota.
DR GeneTree; ENSGT00940000154816; -.
DR HOGENOM; CLU_014430_9_1_1; -.
DR InParanoid; G3TP23; -.
DR OMA; HNHSSFK; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20187; T-box_TBX1_10-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF104; T-BOX TRANSCRIPTION FACTOR TBX1; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 123..306
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 38..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..81
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 53589 MW; 48F7972B1034A3E8 CRC64;
MISAVSSPWL TQLSHFCDVA AFTASSLSSL GAAGGFPGAA SPGADPYGPR EPPPPPPRYD
PCAAAAPGAP GPPPPPHAYP FAPAAGAATS AAAEPEGPGV SCAAAAKAPV KKNVKVASVS
VQLEMKALWD EFNQLGTEMI VTKAGRRMFP TFQVKLFGMD PMADYMLLMD FVPVDDKRYR
YAFHSSSWLV AGKADPATPG RVHYHPDSPA KGAQWMKQIV SFDKLKLTNN LLDDNGHIIL
NSMHRYQPRF HVVYVDPRKD SEKYAEENFK TFVFEETRFT AVTAYQNHRI TQLKIASNPF
AKGFRDCDPE DWPRNHRPGA LPLMSAFARS RNPVASPTQP NGAEKDAAEA RREFERDAGG
PAVLGDPAHT PQLLARVLSP ALPGAGGAGA LVPLPGGRPS PPHPELRLEA PGASEPLHHH
PYKYPAAAYD HYLGAKSRPA PYPLPGLRGH GYHPHAHPHA HPHHHPAVSQ AAAAAAAAAA
AAAANMYSSA GAAPPGSYDY CPR
//
