ID   G3TQR6_LOXAF            Unreviewed;       148 AA.
AC   G3TQR6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSLAFP00000017917.2};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017917.2, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000017917.2, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017917.2,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000017917.2}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017917.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU003753}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC       ECO:0000256|RuleBase:RU003753}.
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DR   AlphaFoldDB; G3TQR6; -.
DR   STRING; 9785.ENSLAFP00000017917; -.
DR   Ensembl; ENSLAFT00000022158.2; ENSLAFP00000017917.2; ENSLAFG00000022694.2.
DR   eggNOG; ENOG502STX9; Eukaryota.
DR   GeneTree; ENSGT00950000182943; -.
DR   HOGENOM; CLU_095373_1_0_1; -.
DR   InParanoid; G3TQR6; -.
DR   OMA; MCLFCED; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10078:SF27; INTERLEUKIN-36 GAMMA; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SMART; SM00125; IL1; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|RuleBase:RU003753}.
SQ   SEQUENCE   148 AA;  16454 MW;  DA63E66ED857977D CRC64;
     PQNGTILDLN HQVWVLQSQT LVAVPRSDSV VPVTVTLIPC KYPESFEQDK GTPIYMGIKN
     PEMCLSCEDV GGQPTLKLKV EKILDLYDQA APVKPFLFYH DKKGRTSTFE SVAFPGWFIA
     SSEIGQPIFL TSELGKAYNT EFDLSIKA
//